The pandemic of coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute re... more The pandemic of coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), current an unparalleled challenge in terms of identifying successful prevention and treatment medications. Clinicians need reliable evidence due to the rapid pace of scientific discovery and clinical data provided by the large number of people infected with SARS-CoV-2. The present review was conducted to summarize the repurposing efficacy of the currently used drugs against COVID-19. Number of antiviral drugs such as remdesivir, favipiravir, chloroquine, hydroxychloroquine, ivermectin, lopinavir, ritonavir has shown inhibitory effects against the SARS-CoV-2 in-vitro as well as in clinical conditions. The immune based therapy like corticosteroids, tocilizumab, baricitinib, casirivimab, and bamlanvimab have shown some promise in more severe cases. Google Scholar, PubMed and SCOPUS were queried using a combination of the keywords "COVID-19," SARS-CoV-2," and "pharmacotherapy." The type of studies that evaluated was clinical trial. Remdesivir has shown the best results and may now be an effective tool for reducing COVID-19 mortality, but more precise and potent antivirals against SARS-CoV-2 would be needed to stop current and/or potential coronavirus pandemics. While, immune based therapy using corticosteroids and anti-SARS-CoV-2 monoclonal antibodies may have their benefit in COVID-19 treatment.
Annona muricata (soursop) is a plant belonging to the Annonaceae family. It's a medicinal herb th... more Annona muricata (soursop) is a plant belonging to the Annonaceae family. It's a medicinal herb that's been used for centuries as a natural cure for a number of diseases. Several investigations in animals showed that the bark and leaves of the plant possessed antihypertensive, vasodilator, anti-spasmodic, and cardio depressive. However, research on soursop fruit is still limited. This study aims to investigate the effect of soursop fruit ethanolic extract on blood glucose, total and Low-Density Lipoprotein (LDL) cholesterol levels in high fat diet and alloxan-induced rats (Rattus novergicus). The study was done experimentally with pre and posttest control group design using 30 rats divided into 6 groups consisted of normal group with standard diet, and five groups induced by high fat diet and alloxan then given 0.9 mg/kg of simvastatin, 0.5 mg/kg glibenclamide, 250 and 500 mg/kg of soursop fruit ethanolic extract (SFEE), and one diabetic hyperglycmia group as positive control without treatment. Blood glucose, total and LDL cholesterol levels measurement was conducted after 21 days of treatment. Data was analyzed using dependent t-test. Results shows significant reduction in blood glucose, total and LDL cholesterol level within treatment groups (p < 0.05). Furthermore, 500 mg/kg SFEE has roughly the same effectiveness as 0.9 mg/kg of simvastatin in reducing the total cholesterol level (p > 0.05), but not for LDL cholesterol. Meanwhile, the effectiveness of 250 and 500 mg/kg SFEE in lowering blood glucose levels is the same as glibenclamide (p > 0.05). In conclusion, SFEE shows hypoglycemic and hypocholesterolemic effect on both dosages.
International Journal of Frontiers in Biology and Pharmacy Research
Gynura divaricata (L.) DC., a traditional medicinal herb, has been used for the treatment of many... more Gynura divaricata (L.) DC., a traditional medicinal herb, has been used for the treatment of many diseases such as bronchitis, pulmonary tuberculosis, pertussis, toothache, rheumatic, arthralgia, uterine bleeding and diabetes in folk medicine. Despite its widespread use, studies on its toxicological characteristics are still very limited. The aim of this research is to observe the acute toxicity of ethanol extract of Gynura divaricata on Deutscland Denken Yoken (DDY) mice. The acute toxicity of ethanol extract of Gynura divaricata leaves was evaluated by giving it orally to DDY mice at single doses of 625, 1250, 2500, and 5000 mg/kg bodyweight. Animals were observed for mortality, body weight changes, macroscopic organ and relative organ weight for the next 14 days, and analyzed with ANOVA and Duncan post hoc test (p<0.05). The results shown ethanol extract of Gynura divaricata leaves did not caused deaths. The gross necropsy analysis did not reveal changes of the organs. Ethanol...
Fatty liver is a disorder of liver characterized by the accumulation of fat liver cells. The inci... more Fatty liver is a disorder of liver characterized by the accumulation of fat liver cells. The incidence of fatty liver in Indonesia is 30%. Fatty liver can be caused by hyperlipidemia. Hyperlipidemia triggers an increase of oxidative stress that leads to fatty liver. Treatment is usually carried out using statins, but long-term consumption of statin may lead to several side effects. Other treatment that can lower cholesterol levels traditionally is celery. This study aimed to determine the effect of ethanol extract of celery on the microscopic appearance of the liver induced by hypercholesterolemia in experimental rats. This was an posttest control group experimental on 25 rats that were divided into 5 groups: negative control group, positive control group, and three (3) treatment groups. Each treatment group was given a high-fat diet for 14 days, followed by a provision of high-fat diet with different celery extract doses of 37.5 mg/KgBW/day, 75 mg/KgBW/day, and 150 mg/KgBW/day. Aft...
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM)
ABSTRAK Resistensi antibiotik terjadi di seluruh dunia. Resistensi antibiotik dipercepat oleh pen... more ABSTRAK Resistensi antibiotik terjadi di seluruh dunia. Resistensi antibiotik dipercepat oleh penyalahgunaan dan penggunaan antibiotik yang berlebihan, serta pencegahan dan pengendalian infeksi yang buruk. Langkah-langkah dapat diambil di semua lapisan masyarakat untuk mengurangi dampak dan membatasi penyebaran resistensi antibiotika. Masyarakat dapat membantu mencegah resistensi dengan menggunakan antibiotika hanya dengan resep dokter, selalu meminum resep dengan lengkap, tidak pernah menggunakan antibiotik sisa dan tidak berbagi antibiotika dengan orang lain. Pengabdian kepada masyarakat ini bertujuan untuk memberikan edukasi kepada masyarakat mengenai cara penggunaan antibiotika secara bijak dan aman. Metode yang digunakan adalah penyuluhan secara daring (webinar) karena masih kondisi pandemi. Pada kegiatan ini juga peserta diberikan kuesioner untuk mengetahui pengetahuan peserta webinar tentang antibiotika. Sebagian besar peserta webinar berjenis kelamin perempuan (91,2%) dengan...
The genus of Terminalia is widespread in southern Asia, the Himalayas, Madagascar, Australia and ... more The genus of Terminalia is widespread in southern Asia, the Himalayas, Madagascar, Australia and Africa. The composition of chemical compounds from the genus of Terminalia consists of terpenoids, tannins, flavonoids, lignans, phenols and glycosides often used in Ayurveda and drugs. β-sitosterol compounds have been isolated from the n-hexane extract of the stems of Ketapang Kencana (T. mantaly) through various chromatographic methods. The chemical structure was identified based on IR, UV spectroscopy, 1H-NMR, 13C-NMR and NMR 2D. The antibacterial activity of n-hexane extract and β-sitosterol compounds was carried out on positive gram bacteria (Staphylococcus aureus, Streptococcus pyogenes) and negative gram bacteria (Shigella dysenteriae and Escherichia coli). The value of the minimum inhibitory concentration (MIC) for extracts and isolates was 0.5 mg/mL respectively.
JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM)
ABSTRAK Perubahan gaya hidup menyebabkan peningkatan angka kejadian penyakit degeneratif seperti ... more ABSTRAK Perubahan gaya hidup menyebabkan peningkatan angka kejadian penyakit degeneratif seperti diabetes mellitus, hipertensi, hiperkolesterolemia di seluruh dunia, termasuk Indonesia. Berbagai metode pengobatan dikembangkan untuk mengatasinya, termasuk penggunaan obat tradisional. Pemerintah Indonesia pun mulai menggalakkan program saintifikasi jamu untuk mendukung hal tersebut. Meningkatnya pemanfaatan lahan keluarga untuk menanam tanaman obat keluarga perlu diimbangi dengan peningkatan pengetahuan masyarakat mengenai bagaimana pemanfaatan tanaman obat keluarga untuk pencegahan dan pengobatan penyakit. Untuk itu maka Tim Pengabdian Masyarakat FK UNJANI bermitra dengan pihak pimpinan kampus untuk melakukan edukasi dalam upaya pemanfaatan tanaman obat keluarga dalam pencegahan dan pengobatan penyakit. Sehubungan masih pandemi COVID-19 metode yang digunakan adalah webinar. Pada kegiatan ini juga peserta diberikan kuesioner untuk mengetahui pengetahuan peserta webinar tentang obat h...
ABSTRAK Belimbing wuluh (Averrhoa bilimbi L) merupakan salah satu tanaman obat yang berpotensi. S... more ABSTRAK Belimbing wuluh (Averrhoa bilimbi L) merupakan salah satu tanaman obat yang berpotensi. Salah satu khasiat dari belimbing wuluh (Averrhoa bilimbi L) yaitu sebagai antidiabetes. Bagian dari tanaman belimbing wuluh yang sering digunakan adalah buah dan daun. Pelarut yang digunakan untuk mengekstraksi belimbing wuluh pada umumnya bersifat polar. Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes ekstrak daun belimbing wuluh dengan tiga pelarut yang berbeda kepolarannya. Daun belimbing wuluh diekstraksi dengan menggunakan pelarut yang berbeda kepolarannya yaitu heksan, etil asetat dan etanol. Semua ekstrak distandarisasi dengan cara dilakukan karakterisasi dan penapisan fitokimia. Selanjutnya ekstrak diuji aktivitas antidiabetes terhadap tikus yang diinduksi aloksan. Empat puluh ekor tikus dibagi menjadi sepuluh kelompok yaitu kelompok kontrol yang diinduksi aloksan dan diberi CMC (Carboxy Methyl Cellulose), kelompok normal yang hanya diberi CMC tanpa induksi aloks...
Sejak WHO mengumumkan keadaan pandemi wabah virus Corona baru atau Coronavirus Disease-19 (COVID-... more Sejak WHO mengumumkan keadaan pandemi wabah virus Corona baru atau Coronavirus Disease-19 (COVID-19), hingga saat ini penularan virus Corona di Indonesia terus bertambah. Upaya untuk menangani pandemi COVID-19, memerlukan kesiapan dan tanggapan yang bersifat kritis seperti memperlengkapi tenaga kesehatan dengan informasi, prosedur, dan alat yang penting agar dapat bekerja dengan aman dan efektif. Puskesmas merupakan ujung tombak pelayanan kesehatan di masyarakat. Tenaga kesehatan berisiko lebih tinggi terinfeksi COVID-19 dalam upayanya melindungi masyarakat lebih luas. Dalam penanganan COVID-19, penggunaan alat pelindung diri (APD) oleh tenaga kesehatan yang terlibat langsung dalam penanganan pasien merupakan hal yang sangat penting. Sebagian besar APD hanya bisa digunakan satu kali dan sebagian kecil bisa digunakan lagi setelah melalui proses sterilisasi. Kota Cimahi merupakan salah satu kota dengan peningkatan kejadian penderita COVID-19 yang sangat pesat. Hal ini menyebabkan tingginya kebutuhan APD dalam jumlah yang memadai dan berkelanjutan di puskesmas. Universitas Jenderal Achmad Yani menyadari pentingnya melindungi tenaga fasilitas pelayanan kesehatan khususnya mereka yang bertugas di puskesmas sebagai garda terdepan. Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan bantuan APD penanganan COVID-19 di Puskesmas-puskesmas yang ada di Kota Cimahi.
International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Ann... more Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were...
Ekstrak kunyit dan bawang putih telah diketahui mempunyai efek antidiabetik, tetapi mekanisme ker... more Ekstrak kunyit dan bawang putih telah diketahui mempunyai efek antidiabetik, tetapi mekanisme kerjanya belum diketahui. Penelitian ini mengamati efek tiga ekstrak rimpang kunyit (Curcuma longa L.) dan bawang putih (Allium sativum L.), yaitu ekstrak heksan, etil asetat, dan etanol terhadap kadar glukosa darah dengan tes toleransi glukosa. Selanjutnya, ekstrak yang paling efektif dan komponen aktifnya (kurkuminoid dan S-metil sistein) diuji dengan tes toleransi insulin. Empat puluh ekor tikus galur Wistar dibagi menjadi 8 kelompok, yaitu kelompok normal, kelompok yang hanya diberi emulsi tinggi lemak (kontrol), dan sisanya selain diberi emulsi tinggi lemak juga masing-masing diberi ekstrak kunyit dengan dosis 50 mg/kgBB, ekstrak bawang putih dengan dosis 50 mg/kgBB, kurkuminoid dengan dosis 25 mg/kgBB, S-metil sistein dengan dosis 25 mg/kgBB, kombinasi ekstrak kunyitbawang putih dengan dosis masing-masing 25 mg/kgBB, dan kombinasi kurkuminoid-S-metil sistein dengan dosis masing-masing 12,5 mg/kgBB selama 10 hari. Resistensi insulin dievaluasi dengan tes toleransi insulin. Penelitian dilakukan pada bulan Agustus-Oktober 2010 di Sekolah Ilmu dan Teknologi Hayati (SITH) Institut Teknologi Bandung (ITB). Hasil penelitian ini menunjukkan bahwa K TTI (konstanta tes toleransi insulin) hewan kelompok ekstrak bawang putih (7,2±0,84), kurkuminoid (7,14±0,74), dan kombinasi kurkuminoid-S-metil sistein (7,46±0,64) secara bermakna (p<0,05) lebih besar dibandingkan dengan kelompok kontrol positif (3,2±1,92). Simpulan, ekstrak bawang putih, kurkuminoid, dan kombinasi kurkuminoid-S-metil sistein meningkatkan sensitivitas insulin. [MKB. 2011;43(4):153-9].
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
The pandemic of coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute re... more The pandemic of coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), current an unparalleled challenge in terms of identifying successful prevention and treatment medications. Clinicians need reliable evidence due to the rapid pace of scientific discovery and clinical data provided by the large number of people infected with SARS-CoV-2. The present review was conducted to summarize the repurposing efficacy of the currently used drugs against COVID-19. Number of antiviral drugs such as remdesivir, favipiravir, chloroquine, hydroxychloroquine, ivermectin, lopinavir, ritonavir has shown inhibitory effects against the SARS-CoV-2 in-vitro as well as in clinical conditions. The immune based therapy like corticosteroids, tocilizumab, baricitinib, casirivimab, and bamlanvimab have shown some promise in more severe cases. Google Scholar, PubMed and SCOPUS were queried using a combination of the keywords "COVID-19," SARS-CoV-2," and "pharmacotherapy." The type of studies that evaluated was clinical trial. Remdesivir has shown the best results and may now be an effective tool for reducing COVID-19 mortality, but more precise and potent antivirals against SARS-CoV-2 would be needed to stop current and/or potential coronavirus pandemics. While, immune based therapy using corticosteroids and anti-SARS-CoV-2 monoclonal antibodies may have their benefit in COVID-19 treatment.
Annona muricata (soursop) is a plant belonging to the Annonaceae family. It's a medicinal herb th... more Annona muricata (soursop) is a plant belonging to the Annonaceae family. It's a medicinal herb that's been used for centuries as a natural cure for a number of diseases. Several investigations in animals showed that the bark and leaves of the plant possessed antihypertensive, vasodilator, anti-spasmodic, and cardio depressive. However, research on soursop fruit is still limited. This study aims to investigate the effect of soursop fruit ethanolic extract on blood glucose, total and Low-Density Lipoprotein (LDL) cholesterol levels in high fat diet and alloxan-induced rats (Rattus novergicus). The study was done experimentally with pre and posttest control group design using 30 rats divided into 6 groups consisted of normal group with standard diet, and five groups induced by high fat diet and alloxan then given 0.9 mg/kg of simvastatin, 0.5 mg/kg glibenclamide, 250 and 500 mg/kg of soursop fruit ethanolic extract (SFEE), and one diabetic hyperglycmia group as positive control without treatment. Blood glucose, total and LDL cholesterol levels measurement was conducted after 21 days of treatment. Data was analyzed using dependent t-test. Results shows significant reduction in blood glucose, total and LDL cholesterol level within treatment groups (p < 0.05). Furthermore, 500 mg/kg SFEE has roughly the same effectiveness as 0.9 mg/kg of simvastatin in reducing the total cholesterol level (p > 0.05), but not for LDL cholesterol. Meanwhile, the effectiveness of 250 and 500 mg/kg SFEE in lowering blood glucose levels is the same as glibenclamide (p > 0.05). In conclusion, SFEE shows hypoglycemic and hypocholesterolemic effect on both dosages.
International Journal of Frontiers in Biology and Pharmacy Research
Gynura divaricata (L.) DC., a traditional medicinal herb, has been used for the treatment of many... more Gynura divaricata (L.) DC., a traditional medicinal herb, has been used for the treatment of many diseases such as bronchitis, pulmonary tuberculosis, pertussis, toothache, rheumatic, arthralgia, uterine bleeding and diabetes in folk medicine. Despite its widespread use, studies on its toxicological characteristics are still very limited. The aim of this research is to observe the acute toxicity of ethanol extract of Gynura divaricata on Deutscland Denken Yoken (DDY) mice. The acute toxicity of ethanol extract of Gynura divaricata leaves was evaluated by giving it orally to DDY mice at single doses of 625, 1250, 2500, and 5000 mg/kg bodyweight. Animals were observed for mortality, body weight changes, macroscopic organ and relative organ weight for the next 14 days, and analyzed with ANOVA and Duncan post hoc test (p<0.05). The results shown ethanol extract of Gynura divaricata leaves did not caused deaths. The gross necropsy analysis did not reveal changes of the organs. Ethanol...
Fatty liver is a disorder of liver characterized by the accumulation of fat liver cells. The inci... more Fatty liver is a disorder of liver characterized by the accumulation of fat liver cells. The incidence of fatty liver in Indonesia is 30%. Fatty liver can be caused by hyperlipidemia. Hyperlipidemia triggers an increase of oxidative stress that leads to fatty liver. Treatment is usually carried out using statins, but long-term consumption of statin may lead to several side effects. Other treatment that can lower cholesterol levels traditionally is celery. This study aimed to determine the effect of ethanol extract of celery on the microscopic appearance of the liver induced by hypercholesterolemia in experimental rats. This was an posttest control group experimental on 25 rats that were divided into 5 groups: negative control group, positive control group, and three (3) treatment groups. Each treatment group was given a high-fat diet for 14 days, followed by a provision of high-fat diet with different celery extract doses of 37.5 mg/KgBW/day, 75 mg/KgBW/day, and 150 mg/KgBW/day. Aft...
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM)
ABSTRAK Resistensi antibiotik terjadi di seluruh dunia. Resistensi antibiotik dipercepat oleh pen... more ABSTRAK Resistensi antibiotik terjadi di seluruh dunia. Resistensi antibiotik dipercepat oleh penyalahgunaan dan penggunaan antibiotik yang berlebihan, serta pencegahan dan pengendalian infeksi yang buruk. Langkah-langkah dapat diambil di semua lapisan masyarakat untuk mengurangi dampak dan membatasi penyebaran resistensi antibiotika. Masyarakat dapat membantu mencegah resistensi dengan menggunakan antibiotika hanya dengan resep dokter, selalu meminum resep dengan lengkap, tidak pernah menggunakan antibiotik sisa dan tidak berbagi antibiotika dengan orang lain. Pengabdian kepada masyarakat ini bertujuan untuk memberikan edukasi kepada masyarakat mengenai cara penggunaan antibiotika secara bijak dan aman. Metode yang digunakan adalah penyuluhan secara daring (webinar) karena masih kondisi pandemi. Pada kegiatan ini juga peserta diberikan kuesioner untuk mengetahui pengetahuan peserta webinar tentang antibiotika. Sebagian besar peserta webinar berjenis kelamin perempuan (91,2%) dengan...
The genus of Terminalia is widespread in southern Asia, the Himalayas, Madagascar, Australia and ... more The genus of Terminalia is widespread in southern Asia, the Himalayas, Madagascar, Australia and Africa. The composition of chemical compounds from the genus of Terminalia consists of terpenoids, tannins, flavonoids, lignans, phenols and glycosides often used in Ayurveda and drugs. β-sitosterol compounds have been isolated from the n-hexane extract of the stems of Ketapang Kencana (T. mantaly) through various chromatographic methods. The chemical structure was identified based on IR, UV spectroscopy, 1H-NMR, 13C-NMR and NMR 2D. The antibacterial activity of n-hexane extract and β-sitosterol compounds was carried out on positive gram bacteria (Staphylococcus aureus, Streptococcus pyogenes) and negative gram bacteria (Shigella dysenteriae and Escherichia coli). The value of the minimum inhibitory concentration (MIC) for extracts and isolates was 0.5 mg/mL respectively.
JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM)
ABSTRAK Perubahan gaya hidup menyebabkan peningkatan angka kejadian penyakit degeneratif seperti ... more ABSTRAK Perubahan gaya hidup menyebabkan peningkatan angka kejadian penyakit degeneratif seperti diabetes mellitus, hipertensi, hiperkolesterolemia di seluruh dunia, termasuk Indonesia. Berbagai metode pengobatan dikembangkan untuk mengatasinya, termasuk penggunaan obat tradisional. Pemerintah Indonesia pun mulai menggalakkan program saintifikasi jamu untuk mendukung hal tersebut. Meningkatnya pemanfaatan lahan keluarga untuk menanam tanaman obat keluarga perlu diimbangi dengan peningkatan pengetahuan masyarakat mengenai bagaimana pemanfaatan tanaman obat keluarga untuk pencegahan dan pengobatan penyakit. Untuk itu maka Tim Pengabdian Masyarakat FK UNJANI bermitra dengan pihak pimpinan kampus untuk melakukan edukasi dalam upaya pemanfaatan tanaman obat keluarga dalam pencegahan dan pengobatan penyakit. Sehubungan masih pandemi COVID-19 metode yang digunakan adalah webinar. Pada kegiatan ini juga peserta diberikan kuesioner untuk mengetahui pengetahuan peserta webinar tentang obat h...
ABSTRAK Belimbing wuluh (Averrhoa bilimbi L) merupakan salah satu tanaman obat yang berpotensi. S... more ABSTRAK Belimbing wuluh (Averrhoa bilimbi L) merupakan salah satu tanaman obat yang berpotensi. Salah satu khasiat dari belimbing wuluh (Averrhoa bilimbi L) yaitu sebagai antidiabetes. Bagian dari tanaman belimbing wuluh yang sering digunakan adalah buah dan daun. Pelarut yang digunakan untuk mengekstraksi belimbing wuluh pada umumnya bersifat polar. Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes ekstrak daun belimbing wuluh dengan tiga pelarut yang berbeda kepolarannya. Daun belimbing wuluh diekstraksi dengan menggunakan pelarut yang berbeda kepolarannya yaitu heksan, etil asetat dan etanol. Semua ekstrak distandarisasi dengan cara dilakukan karakterisasi dan penapisan fitokimia. Selanjutnya ekstrak diuji aktivitas antidiabetes terhadap tikus yang diinduksi aloksan. Empat puluh ekor tikus dibagi menjadi sepuluh kelompok yaitu kelompok kontrol yang diinduksi aloksan dan diberi CMC (Carboxy Methyl Cellulose), kelompok normal yang hanya diberi CMC tanpa induksi aloks...
Sejak WHO mengumumkan keadaan pandemi wabah virus Corona baru atau Coronavirus Disease-19 (COVID-... more Sejak WHO mengumumkan keadaan pandemi wabah virus Corona baru atau Coronavirus Disease-19 (COVID-19), hingga saat ini penularan virus Corona di Indonesia terus bertambah. Upaya untuk menangani pandemi COVID-19, memerlukan kesiapan dan tanggapan yang bersifat kritis seperti memperlengkapi tenaga kesehatan dengan informasi, prosedur, dan alat yang penting agar dapat bekerja dengan aman dan efektif. Puskesmas merupakan ujung tombak pelayanan kesehatan di masyarakat. Tenaga kesehatan berisiko lebih tinggi terinfeksi COVID-19 dalam upayanya melindungi masyarakat lebih luas. Dalam penanganan COVID-19, penggunaan alat pelindung diri (APD) oleh tenaga kesehatan yang terlibat langsung dalam penanganan pasien merupakan hal yang sangat penting. Sebagian besar APD hanya bisa digunakan satu kali dan sebagian kecil bisa digunakan lagi setelah melalui proses sterilisasi. Kota Cimahi merupakan salah satu kota dengan peningkatan kejadian penderita COVID-19 yang sangat pesat. Hal ini menyebabkan tingginya kebutuhan APD dalam jumlah yang memadai dan berkelanjutan di puskesmas. Universitas Jenderal Achmad Yani menyadari pentingnya melindungi tenaga fasilitas pelayanan kesehatan khususnya mereka yang bertugas di puskesmas sebagai garda terdepan. Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan bantuan APD penanganan COVID-19 di Puskesmas-puskesmas yang ada di Kota Cimahi.
International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Ann... more Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were...
Ekstrak kunyit dan bawang putih telah diketahui mempunyai efek antidiabetik, tetapi mekanisme ker... more Ekstrak kunyit dan bawang putih telah diketahui mempunyai efek antidiabetik, tetapi mekanisme kerjanya belum diketahui. Penelitian ini mengamati efek tiga ekstrak rimpang kunyit (Curcuma longa L.) dan bawang putih (Allium sativum L.), yaitu ekstrak heksan, etil asetat, dan etanol terhadap kadar glukosa darah dengan tes toleransi glukosa. Selanjutnya, ekstrak yang paling efektif dan komponen aktifnya (kurkuminoid dan S-metil sistein) diuji dengan tes toleransi insulin. Empat puluh ekor tikus galur Wistar dibagi menjadi 8 kelompok, yaitu kelompok normal, kelompok yang hanya diberi emulsi tinggi lemak (kontrol), dan sisanya selain diberi emulsi tinggi lemak juga masing-masing diberi ekstrak kunyit dengan dosis 50 mg/kgBB, ekstrak bawang putih dengan dosis 50 mg/kgBB, kurkuminoid dengan dosis 25 mg/kgBB, S-metil sistein dengan dosis 25 mg/kgBB, kombinasi ekstrak kunyitbawang putih dengan dosis masing-masing 25 mg/kgBB, dan kombinasi kurkuminoid-S-metil sistein dengan dosis masing-masing 12,5 mg/kgBB selama 10 hari. Resistensi insulin dievaluasi dengan tes toleransi insulin. Penelitian dilakukan pada bulan Agustus-Oktober 2010 di Sekolah Ilmu dan Teknologi Hayati (SITH) Institut Teknologi Bandung (ITB). Hasil penelitian ini menunjukkan bahwa K TTI (konstanta tes toleransi insulin) hewan kelompok ekstrak bawang putih (7,2±0,84), kurkuminoid (7,14±0,74), dan kombinasi kurkuminoid-S-metil sistein (7,46±0,64) secara bermakna (p<0,05) lebih besar dibandingkan dengan kelompok kontrol positif (3,2±1,92). Simpulan, ekstrak bawang putih, kurkuminoid, dan kombinasi kurkuminoid-S-metil sistein meningkatkan sensitivitas insulin. [MKB. 2011;43(4):153-9].
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021), 2021
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