Tympanoplasty is a gold standard treatment for drum perforations. Many different grafts were stud... more Tympanoplasty is a gold standard treatment for drum perforations. Many different grafts were studied being temporalis fascia and cartilage the more routinely used nowadays. Nasal mucosa is an interesting alternative graft, but there are few papers showing its safety and effectiveness. In this controlled randomized clinical trial, we compared surgical and audiological results of nasal mucosa graft versus temporalis fascia, in 40 patients that underwent tympanoplasty, divided in 2 groups of 20 patients for each graft. Both groups had 85% of surgical success and mean audiological gain was 11,9 dB for nasal mucosa and 11,1 dB for temporalis fascia, with no statistical significant difference between groups. No complications happened in anygroups. Nasal mucosa is a good alternative graft for tympanoplasty. Further studies are necessary for nasal mucosa to achieve levels of evidence similar as temporalis fascia and cartilage grafts.
Background: An analysis of the impact of the coronavirus disease 2019 (COVID-19) on the patterns ... more Background: An analysis of the impact of the coronavirus disease 2019 (COVID-19) on the patterns of treatment and the safety for patients with early breast cancer (EBC). Methods: This was an observational real-world study. A total of 958 EBC patients who were admitted to two groups during the epidemic (Observation group: Q1 in 2020, n=422) and the similar time frame from last year (Control group: Q1 in 2019, n=536). The primary end point of the study was the overall safety of treatments, including the proportion of neutropenia, fever, infection and infection of COVID-19. The secondary end point is the treatment patterns, referring to different treatment methods and the proportion of different regimens. Results: Under the guidance of specific treatment strategies, the patient's treatment patterns have changed significantly. Among them, the proportion of albumin paclitaxel in the observation group was significantly increased (55.8% vs. 13.0%, P<0.001) compared with the control group, and the proportion of docetaxel was significantly reduced (30.4% vs. 70.1%, P<0.001). The proportion of anthracycline drugs and vinorelbine decreased (both P<0.05). In the observation group, 22.5% of patients had neutropenia, which was significantly lower than the control group (22.5% vs. 50.6%, P<0.05), and the incidence of fever in the observation group was lower than that of the control group (P=0.05). Conclusions: The patient's treatment patterns were significantly changed during COVID-19 pandemic, and optimized treatment strategy is suitable for breast cancer patients that can ensure the patient's treatment needs and overall safety.
Introduction: Tympanoplasty techniques with different types of graft have been used to close tymp... more Introduction: Tympanoplasty techniques with different types of graft have been used to close tympanic perforations since the 19th century. Tragal cartilage and temporalis fascia are the most frequently used types of graft. They lead to similar functional and morphological results in most cases. Although little published evidence is present, nasal mucosa has also been shown to be a good alternative graft. Objective: Surgical and audiological outcomes at the six-month follow-up in type I tympanoplasty using nasal mucosa and temporalis fascia grafts were analyzed. Methods: A total of 40 candidates for type I tympanoplasty were randomly selected and divided into the nasal mucosa and temporalis fascia graft groups with 20 in each group. The assessed parameters included surgical success; the rate of complete closure of tympanic perforation and hearing results; the difference between post-and pre-operative mean quadritonal airway-bone gap, six months after surgery. Results: Complete closure of the tympanic perforation was achieved in 17 of 20 patients in both groups. The mean quadritonal airway-bone gap closures were11.9 and 11.1 dB for the nasal mucosa and temporalis fascia groups, respectively. There was no statistically significant difference between the groups. Conclusion: The nasal mucosa graft can be considered similar to the temporal fascia when considering the surgical success rate of graft acceptance and ultimate audiological gain.
Tympanoplasty is a gold standard treatment for drum perforations. Many different grafts were stud... more Tympanoplasty is a gold standard treatment for drum perforations. Many different grafts were studied being temporalis fascia and cartilage the more routinely used nowadays. Nasal mucosa is an interesting alternative graft, but there are few papers showing its safety and effectiveness. In this controlled randomized clinical trial, we compared surgical and audiological results of nasal mucosa graft versus temporalis fascia, in 40 patients that underwent tympanoplasty, divided in 2 groups of 20 patients for each graft. Both groups had 85% of surgical success and mean audiological gain was 11,9 dB for nasal mucosa and 11,1 dB for temporalis fascia, with no statistical significant difference between groups. No complications happened in anygroups. Nasal mucosa is a good alternative graft for tympanoplasty. Further studies are necessary for nasal mucosa to achieve levels of evidence similar as temporalis fascia and cartilage grafts.
Background: An analysis of the impact of the coronavirus disease 2019 (COVID-19) on the patterns ... more Background: An analysis of the impact of the coronavirus disease 2019 (COVID-19) on the patterns of treatment and the safety for patients with early breast cancer (EBC). Methods: This was an observational real-world study. A total of 958 EBC patients who were admitted to two groups during the epidemic (Observation group: Q1 in 2020, n=422) and the similar time frame from last year (Control group: Q1 in 2019, n=536). The primary end point of the study was the overall safety of treatments, including the proportion of neutropenia, fever, infection and infection of COVID-19. The secondary end point is the treatment patterns, referring to different treatment methods and the proportion of different regimens. Results: Under the guidance of specific treatment strategies, the patient's treatment patterns have changed significantly. Among them, the proportion of albumin paclitaxel in the observation group was significantly increased (55.8% vs. 13.0%, P<0.001) compared with the control group, and the proportion of docetaxel was significantly reduced (30.4% vs. 70.1%, P<0.001). The proportion of anthracycline drugs and vinorelbine decreased (both P<0.05). In the observation group, 22.5% of patients had neutropenia, which was significantly lower than the control group (22.5% vs. 50.6%, P<0.05), and the incidence of fever in the observation group was lower than that of the control group (P=0.05). Conclusions: The patient's treatment patterns were significantly changed during COVID-19 pandemic, and optimized treatment strategy is suitable for breast cancer patients that can ensure the patient's treatment needs and overall safety.
Introduction: Tympanoplasty techniques with different types of graft have been used to close tymp... more Introduction: Tympanoplasty techniques with different types of graft have been used to close tympanic perforations since the 19th century. Tragal cartilage and temporalis fascia are the most frequently used types of graft. They lead to similar functional and morphological results in most cases. Although little published evidence is present, nasal mucosa has also been shown to be a good alternative graft. Objective: Surgical and audiological outcomes at the six-month follow-up in type I tympanoplasty using nasal mucosa and temporalis fascia grafts were analyzed. Methods: A total of 40 candidates for type I tympanoplasty were randomly selected and divided into the nasal mucosa and temporalis fascia graft groups with 20 in each group. The assessed parameters included surgical success; the rate of complete closure of tympanic perforation and hearing results; the difference between post-and pre-operative mean quadritonal airway-bone gap, six months after surgery. Results: Complete closure of the tympanic perforation was achieved in 17 of 20 patients in both groups. The mean quadritonal airway-bone gap closures were11.9 and 11.1 dB for the nasal mucosa and temporalis fascia groups, respectively. There was no statistically significant difference between the groups. Conclusion: The nasal mucosa graft can be considered similar to the temporal fascia when considering the surgical success rate of graft acceptance and ultimate audiological gain.
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