Follicular helper T lymphocytes (TFH) are essential to establish a correct and protective humoral... more Follicular helper T lymphocytes (TFH) are essential to establish a correct and protective humoral immune response. Correct regulation of their development and differentiation is necessary to achieve a normal antibody response. They can be characterized by their phenotype and function. It has been proposed that their role is important in the generation of immunodeficiency or autoimmunity, as well as in the control of chronic viral or protozoan infections. This review comments recent advances in human TFH research that may be useful in order to design adequate therapeutic or vaccination strategies.
El virus de la hepatitis C (HCV) fue identificado por primera vez en los EE.UU. en el año 1989 co... more El virus de la hepatitis C (HCV) fue identificado por primera vez en los EE.UU. en el año 1989 como el mayor causante de las llamadas hepatitis no A no B post transfusionales. En aproximadamente el 85% de los casos, el sistema inmune no es capaz de erradicar la infección y el virus persiste en el individuo. Los individuos con infección crónica tienen un riesgo elevado de desarrollar enfermedades hepáticas crónicas con un amplio espectro de manifestaciones clínicas que incluyen la cirrosis y el hepatocarcinoma.Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentin
Dendritic cells are most important as antigen presenting cells during the induction of an effecti... more Dendritic cells are most important as antigen presenting cells during the induction of an effective immune response. Therefore, it is important to study their role during the generation of persistent or chronic viral infections, such as HIV or HCV infection. In this review we shall describe the phenotypic and functional characteristics of the different classes of dendritic cells and of their membrane receptors. Their participation in defence or facilitation mechanisms involved in the immune response against these viruses will be discussed. It is important to take this knowledge into account when trying to design therapeutic strategies for protection or reconstruction of the immune system that may be altered as a consequence of infection with HIV or HCV.
Mutations in SH2D1A, a gene that codifies for the regulatory protein SAP, result in uncontrolled ... more Mutations in SH2D1A, a gene that codifies for the regulatory protein SAP, result in uncontrolled activation of the SLAM (signaling lymphocyte-activation molecule) pathway. This X-linked immunodeficiency becomes evident when the patients are infected with Epstein Barr virus (EBV) and develop a fulminant form of infectious mononucleosis leading to a lymphoproliferative syndrome that is often fatal (X-linked lymphoproliferative syndrome, XLP). In those who survive, hypogammaglobulinemia and oncohematologic diseases are frequently observed. In this revision, the immuno-regulatory mechanisms involved in XLP immunopathology and the role of different effector cells (CD8 T lymphocytes, NK cells) are discussed.
SummaryWe have analysed the phenotype of T lymphocytes in two X-linked lymphoproliferative diseas... more SummaryWe have analysed the phenotype of T lymphocytes in two X-linked lymphoproliferative disease (XLP) patients with the same SH2D1A mutation differing in initial exposure to Epstein–Barr virus (EBV) and treatment. While memory T lymphocytes (with low CCR7 and CD62L expression) prevailed in both XLP patients, in patient 9, who developed acute infectious mononucleosis (AIM) and received B cell ablative treatment, the predominant phenotype was that of late effector CD8 T cells (CD27–, CD28–, CCR7–, CD62L–, CD45 RA+, perforin+), while in patient 4 (who did not suffer AIM) the prevalent phenotype of CD8 T lymphocytes was similar to that of normal controls (N) or to that of adult individuals who recovered from AIM: CD27+ , CD28+, CCR7–, CD62L–, CD45 RO+ and perforin–. CD57 expression (related to senescence) was also higher in CD8 T cells from patient 9 than in patient 4, AIM or N. Persistently high EBV viral load was observed in patient 9. The results obtained from this limited number ...
Detailed longitudinal studies of patients with X-linked lymphoproliferative disease (XLP) may inc... more Detailed longitudinal studies of patients with X-linked lymphoproliferative disease (XLP) may increase our understanding of the immunologic defects that contribute to the development of lymphoma and hypogammaglobulinemia in XLP. We describe progressive changes observed in immunoglobulin concentrations, lymphocyte subsets, and Epstein-Barr virus (EBV) loads occurring in a 2-year period in a newly infected, but otherwise healthy, carrier (patient 9). We compare these findings with those observed in the patient's brother, who had hypogammaglobulinemia and XLP (patient 4). Immunoglobulin G (IgG), IgM, and IgA concentrations increased in patient 9 during acute EBV infection, but thereafter they decreased steadily to concentrations consistent with hypogammaglobulinemia, reaching a plateau 5 months after infection. In both patients, CD19+ B-lymphocyte rates remained lower than 3%, with a contraction of the B-cell memory compartment (CD27+ CD19+/CD19+) to 20% (normal range, 32%-56%). T-...
In order to investigate hepatitis C virus (HCV) persistence and replication in peripheral blood m... more In order to investigate hepatitis C virus (HCV) persistence and replication in peripheral blood mononuclear cells (PBMC) from a group of haemophilic individuals, HCV production and release to PBMC culture supernatants (SNs) from HCV singly infected patients and HIV/HCV co-...
Background: The estimated prevalence of HCV infection in Argentina is around 2%. However, higher ... more Background: The estimated prevalence of HCV infection in Argentina is around 2%. However, higher rates of infection have been described in population studies of small urban and rural communities. The aim of this work was to compare the origin and diversification of HCV-1b in samples from two different epidemiological scenarios: Buenos Aires, a large cosmopolitan city, and O'Brien, a small rural town with a high prevalence of HCV infection.
Follicular helper T lymphocytes (TFH) are essential to establish a correct and protective humoral... more Follicular helper T lymphocytes (TFH) are essential to establish a correct and protective humoral immune response. Correct regulation of their development and differentiation is necessary to achieve a normal antibody response. They can be characterized by their phenotype and function. It has been proposed that their role is important in the generation of immunodeficiency or autoimmunity, as well as in the control of chronic viral or protozoan infections. This review comments recent advances in human TFH research that may be useful in order to design adequate therapeutic or vaccination strategies.
El virus de la hepatitis C (HCV) fue identificado por primera vez en los EE.UU. en el año 1989 co... more El virus de la hepatitis C (HCV) fue identificado por primera vez en los EE.UU. en el año 1989 como el mayor causante de las llamadas hepatitis no A no B post transfusionales. En aproximadamente el 85% de los casos, el sistema inmune no es capaz de erradicar la infección y el virus persiste en el individuo. Los individuos con infección crónica tienen un riesgo elevado de desarrollar enfermedades hepáticas crónicas con un amplio espectro de manifestaciones clínicas que incluyen la cirrosis y el hepatocarcinoma.Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentin
Dendritic cells are most important as antigen presenting cells during the induction of an effecti... more Dendritic cells are most important as antigen presenting cells during the induction of an effective immune response. Therefore, it is important to study their role during the generation of persistent or chronic viral infections, such as HIV or HCV infection. In this review we shall describe the phenotypic and functional characteristics of the different classes of dendritic cells and of their membrane receptors. Their participation in defence or facilitation mechanisms involved in the immune response against these viruses will be discussed. It is important to take this knowledge into account when trying to design therapeutic strategies for protection or reconstruction of the immune system that may be altered as a consequence of infection with HIV or HCV.
Mutations in SH2D1A, a gene that codifies for the regulatory protein SAP, result in uncontrolled ... more Mutations in SH2D1A, a gene that codifies for the regulatory protein SAP, result in uncontrolled activation of the SLAM (signaling lymphocyte-activation molecule) pathway. This X-linked immunodeficiency becomes evident when the patients are infected with Epstein Barr virus (EBV) and develop a fulminant form of infectious mononucleosis leading to a lymphoproliferative syndrome that is often fatal (X-linked lymphoproliferative syndrome, XLP). In those who survive, hypogammaglobulinemia and oncohematologic diseases are frequently observed. In this revision, the immuno-regulatory mechanisms involved in XLP immunopathology and the role of different effector cells (CD8 T lymphocytes, NK cells) are discussed.
SummaryWe have analysed the phenotype of T lymphocytes in two X-linked lymphoproliferative diseas... more SummaryWe have analysed the phenotype of T lymphocytes in two X-linked lymphoproliferative disease (XLP) patients with the same SH2D1A mutation differing in initial exposure to Epstein–Barr virus (EBV) and treatment. While memory T lymphocytes (with low CCR7 and CD62L expression) prevailed in both XLP patients, in patient 9, who developed acute infectious mononucleosis (AIM) and received B cell ablative treatment, the predominant phenotype was that of late effector CD8 T cells (CD27–, CD28–, CCR7–, CD62L–, CD45 RA+, perforin+), while in patient 4 (who did not suffer AIM) the prevalent phenotype of CD8 T lymphocytes was similar to that of normal controls (N) or to that of adult individuals who recovered from AIM: CD27+ , CD28+, CCR7–, CD62L–, CD45 RO+ and perforin–. CD57 expression (related to senescence) was also higher in CD8 T cells from patient 9 than in patient 4, AIM or N. Persistently high EBV viral load was observed in patient 9. The results obtained from this limited number ...
Detailed longitudinal studies of patients with X-linked lymphoproliferative disease (XLP) may inc... more Detailed longitudinal studies of patients with X-linked lymphoproliferative disease (XLP) may increase our understanding of the immunologic defects that contribute to the development of lymphoma and hypogammaglobulinemia in XLP. We describe progressive changes observed in immunoglobulin concentrations, lymphocyte subsets, and Epstein-Barr virus (EBV) loads occurring in a 2-year period in a newly infected, but otherwise healthy, carrier (patient 9). We compare these findings with those observed in the patient's brother, who had hypogammaglobulinemia and XLP (patient 4). Immunoglobulin G (IgG), IgM, and IgA concentrations increased in patient 9 during acute EBV infection, but thereafter they decreased steadily to concentrations consistent with hypogammaglobulinemia, reaching a plateau 5 months after infection. In both patients, CD19+ B-lymphocyte rates remained lower than 3%, with a contraction of the B-cell memory compartment (CD27+ CD19+/CD19+) to 20% (normal range, 32%-56%). T-...
In order to investigate hepatitis C virus (HCV) persistence and replication in peripheral blood m... more In order to investigate hepatitis C virus (HCV) persistence and replication in peripheral blood mononuclear cells (PBMC) from a group of haemophilic individuals, HCV production and release to PBMC culture supernatants (SNs) from HCV singly infected patients and HIV/HCV co-...
Background: The estimated prevalence of HCV infection in Argentina is around 2%. However, higher ... more Background: The estimated prevalence of HCV infection in Argentina is around 2%. However, higher rates of infection have been described in population studies of small urban and rural communities. The aim of this work was to compare the origin and diversification of HCV-1b in samples from two different epidemiological scenarios: Buenos Aires, a large cosmopolitan city, and O'Brien, a small rural town with a high prevalence of HCV infection.
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Papers by Patricia Baré