Current Issues in Pharmacy and Medical Sciences, 2013
Development of experimental diabetes mellitus in rats was accompanied by increase of desialylatio... more Development of experimental diabetes mellitus in rats was accompanied by increase of desialylation of carbohydrate determinants of leukocyte membrane glycoproteins. A decreased level of both (2,3)and (2,6)-linked sialic acid residues and uncovering the penultimate galactose residues was shown. Our findings shown increase in sialation (in particular (2,3) sialation) of oligosaccharide sequences of leukocytes membrane glycoconjugates after treatment diabetic rats with agmatine. Detected changes in configuration of leukocyte membrane components in diabetic animals after agmatine administration indicate the positively effects of this polyamine due to its hypoglycemic effect.
Background. According to the International Diabetes Federation Diabetes Atlas, 10th edition, diab... more Background. According to the International Diabetes Federation Diabetes Atlas, 10th edition, diabetes is responsible for 6.7 million deaths in 2021. Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia secondary to either resistance to insulin, insufficient insulin secretion, or both. Oxidative and nitrative stress is a vital part of the complex mechanism by which diabetes and its complications develop. It is known that Photobiomodulation therapy accelerates diabetic wound healing, treats relegated inflammation, and increases oxygen availability for cells. Although some basic molecular mechanisms caused by photobiomodulation therapy in different cell types are already known, they have not been studied in erythrocytes and are different due to the absence of central organelles such as nucleus and mitochondria. The aim of the study was to investigate the effect of photobiomodulation therapy on the development of nitrative stress in blood plasma and erythro...
For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is ... more For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is vital to understand the regulatory mechanisms that control the work of glucose transporters. Lymphocytes are pivotal for mediation of immune and inflammatory responses. A feature of lymphocytes is increasing glucose utilization during activation of the immune function, which is strongly dependent on glucose uptake. Some studies show that elevated glucose concentration in diabetes mellitus affects lymphocytes’ glucose transporters expression, whichcorrelates with impaired immune functions and may become one of the predisposing factors of contracting infectious diseases. Recent studies have focused on glucose transporters as therapeutic targets for a variety of diseases, including diabetes mellitus. This review demonstrates the effect of photobiomodulationtherapy on glucose uptake by Na+-coupled glucose carrier SGLT1 and facilitated diffusion glucose carriers of the GLUT family (GLUT1, GLU...
For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is ... more For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is vital to understand the regulatory mechanisms that control the work of glucose transporters. Lymphocytes are pivotal for mediation of immune and inflammatory responses. A feature of lymphocytes is increasing glucose utilization during activation of the immune function, which is strongly dependent on glucose uptake. Some studies show that elevated glucose concentration in diabetes mellitus affects lymphocytes’ glucose transporters expression, which correlates with impaired immune functions and may become one of the predisposing factors of contracting infectious diseases. Recent studies have focused on glucose transporters as therapeutic targets for a variety of diseases, including diabetes mellitus. This review demonstrates the effect of photobiomodulation therapy on glucose uptake by Na+-coupled glucose carrier SGLT1 and facilitated diffusion glucose carriers of the GLUT family (GLUT1, GLUT3, GLUT4) in normal and diabetic lymphocytes.
Current Issues in Pharmacy and Medical Sciences, 2013
Development of experimental diabetes mellitus in rats was accompanied by increase of desialylatio... more Development of experimental diabetes mellitus in rats was accompanied by increase of desialylation of carbohydrate determinants of leukocyte membrane glycoproteins. A decreased level of both (2,3)and (2,6)-linked sialic acid residues and uncovering the penultimate galactose residues was shown. Our findings shown increase in sialation (in particular (2,3) sialation) of oligosaccharide sequences of leukocytes membrane glycoconjugates after treatment diabetic rats with agmatine. Detected changes in configuration of leukocyte membrane components in diabetic animals after agmatine administration indicate the positively effects of this polyamine due to its hypoglycemic effect.
Current Issues in Pharmacy and Medical Sciences, 2013
Development of experimental diabetes mellitus in rats was accompanied by increase of desialylatio... more Development of experimental diabetes mellitus in rats was accompanied by increase of desialylation of carbohydrate determinants of leukocyte membrane glycoproteins. A decreased level of both (2,3)and (2,6)-linked sialic acid residues and uncovering the penultimate galactose residues was shown. Our findings shown increase in sialation (in particular (2,3) sialation) of oligosaccharide sequences of leukocytes membrane glycoconjugates after treatment diabetic rats with agmatine. Detected changes in configuration of leukocyte membrane components in diabetic animals after agmatine administration indicate the positively effects of this polyamine due to its hypoglycemic effect.
Background. According to the International Diabetes Federation Diabetes Atlas, 10th edition, diab... more Background. According to the International Diabetes Federation Diabetes Atlas, 10th edition, diabetes is responsible for 6.7 million deaths in 2021. Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia secondary to either resistance to insulin, insufficient insulin secretion, or both. Oxidative and nitrative stress is a vital part of the complex mechanism by which diabetes and its complications develop. It is known that Photobiomodulation therapy accelerates diabetic wound healing, treats relegated inflammation, and increases oxygen availability for cells. Although some basic molecular mechanisms caused by photobiomodulation therapy in different cell types are already known, they have not been studied in erythrocytes and are different due to the absence of central organelles such as nucleus and mitochondria. The aim of the study was to investigate the effect of photobiomodulation therapy on the development of nitrative stress in blood plasma and erythro...
For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is ... more For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is vital to understand the regulatory mechanisms that control the work of glucose transporters. Lymphocytes are pivotal for mediation of immune and inflammatory responses. A feature of lymphocytes is increasing glucose utilization during activation of the immune function, which is strongly dependent on glucose uptake. Some studies show that elevated glucose concentration in diabetes mellitus affects lymphocytes’ glucose transporters expression, whichcorrelates with impaired immune functions and may become one of the predisposing factors of contracting infectious diseases. Recent studies have focused on glucose transporters as therapeutic targets for a variety of diseases, including diabetes mellitus. This review demonstrates the effect of photobiomodulationtherapy on glucose uptake by Na+-coupled glucose carrier SGLT1 and facilitated diffusion glucose carriers of the GLUT family (GLUT1, GLU...
For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is ... more For most cells, including lymphocytes, glucose is a primary energy source, and, therefore, it is vital to understand the regulatory mechanisms that control the work of glucose transporters. Lymphocytes are pivotal for mediation of immune and inflammatory responses. A feature of lymphocytes is increasing glucose utilization during activation of the immune function, which is strongly dependent on glucose uptake. Some studies show that elevated glucose concentration in diabetes mellitus affects lymphocytes’ glucose transporters expression, which correlates with impaired immune functions and may become one of the predisposing factors of contracting infectious diseases. Recent studies have focused on glucose transporters as therapeutic targets for a variety of diseases, including diabetes mellitus. This review demonstrates the effect of photobiomodulation therapy on glucose uptake by Na+-coupled glucose carrier SGLT1 and facilitated diffusion glucose carriers of the GLUT family (GLUT1, GLUT3, GLUT4) in normal and diabetic lymphocytes.
Current Issues in Pharmacy and Medical Sciences, 2013
Development of experimental diabetes mellitus in rats was accompanied by increase of desialylatio... more Development of experimental diabetes mellitus in rats was accompanied by increase of desialylation of carbohydrate determinants of leukocyte membrane glycoproteins. A decreased level of both (2,3)and (2,6)-linked sialic acid residues and uncovering the penultimate galactose residues was shown. Our findings shown increase in sialation (in particular (2,3) sialation) of oligosaccharide sequences of leukocytes membrane glycoconjugates after treatment diabetic rats with agmatine. Detected changes in configuration of leukocyte membrane components in diabetic animals after agmatine administration indicate the positively effects of this polyamine due to its hypoglycemic effect.
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