Background: Omalizumab is a third-line treatment for chronic spontaneous urticaria (CSU). However... more Background: Omalizumab is a third-line treatment for chronic spontaneous urticaria (CSU). However the real-life data on the impact of omalizumab on CSU-related quality of life (QoL) remains scarce. Objectives: To investigate the impact of omalizumab on QoL and its predictors in CSU. Methods: A retrospective cohort study was done. The response to therapy was evaluated using urticaria activity score over 7 days (UAS7) and urticaria control test (UCT); the impairment in QoL was assessed using Dermatology Life Quality Index (DLQI) and Chronic Urticaria and Quality of Life Questionnaire (CU-Q2oL). Results: Forty-two patients were included. All scores improved from baseline to first month and remained stable at the third month of treatment (P<0.001). The gender, age and angioedema had no significant effect on QoL, but the complete responders (UAS7:0-1) had better improvement rates in all scores compared to others. The baseline UAS7, DLQI and CU-Q2oL scores were lower at the baseline in complete responders (p=0.0001). Conclusions: A rapid and continual improvement in QoL was obtained with omalizumab treatment. A better UAS7, UCT, DLQI, and CU-Q2oL score at the baseline might be a predictor of a better response to omalizumab and more improvement in QoL.
Background: Omalizumab is a third-line treatment for chronic spontaneous urticaria (CSU). However... more Background: Omalizumab is a third-line treatment for chronic spontaneous urticaria (CSU). However the real-life data on the impact of omalizumab on CSU-related quality of life (QoL) remains scarce. Objectives: To investigate the impact of omalizumab on QoL and its predictors in CSU. Methods: A retrospective cohort study was done. The response to therapy was evaluated using urticaria activity score over 7 days (UAS7) and urticaria control test (UCT); the impairment in QoL was assessed using Dermatology Life Quality Index (DLQI) and Chronic Urticaria and Quality of Life Questionnaire (CU-Q2oL). Results: Forty-two patients were included. All scores improved from baseline to first month and remained stable at the third month of treatment (P<0.001). The gender, age and angioedema had no significant effect on QoL, but the complete responders (UAS7:0-1) had better improvement rates in all scores compared to others. The baseline UAS7, DLQI and CU-Q2oL scores were lower at the baseline in complete responders (p=0.0001). Conclusions: A rapid and continual improvement in QoL was obtained with omalizumab treatment. A better UAS7, UCT, DLQI, and CU-Q2oL score at the baseline might be a predictor of a better response to omalizumab and more improvement in QoL.
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Papers by Gizem Demir