Papers by Catherine Milte
Prostaglandins Leukotrienes and Essential Fatty Acids, 2011
Polyunsaturated fatty acid (PUFA) levels are altered in adults with cognitive decline and also de... more Polyunsaturated fatty acid (PUFA) levels are altered in adults with cognitive decline and also depression. Depression facilitates progression from mild cognitive impairment (MCI) to dementia. We investigated associations between omega-3 (n-3) and omega-6 (n-6) PUFAs and cognition, memory and depression in 50 adults Z 65 years with MCI and 29 controls. Memory, depressive symptoms and erythrocyte PUFAs (% total fatty acids) were assessed. Eicosapentaenoic acid (EPA) was lower in MCI vs controls (.94% vs 1.26%, po .01); n-6 PUFAs were higher: dihomo-gamma-linolenic acid (1.51% vs 1.32%, po .01), arachidonic acid (11.54% vs 10.70%, po .01), n-6 docosapentaenoic acid (DPA:.46% vs.34%, po .01), and total n-6 PUFA (24.14% vs 23.37%, p o .05). Higher n-6 DPA predicted poorer mental health. Lower n-3 DPA was associated with higher self-reported bodily pain. Adults with MCI had higher depression scores (3.05 7 .39 vs 1.33 7 .24, po .01). Depressive symptoms associated with elevated n-6 PUFA may contribute to cognitive decline in this population.
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Papers by Catherine Milte