This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a ... more This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide. Methods: We analysed 189 VAIN 2/3 and 408 invasive vaginal cancer cases collected from 31 countries from 1986 to 2011. After histopathological evaluation of sectioned formalin-fixed paraffin-embedded samples, HPV DNA detection and typing was performed using the SPF-10/DNA enzyme immunoassay (DEIA)/LiPA 25 system (version 1). A subset of 146 vaginal cancers was tested for p16 INK4a expression, a cellular surrogate marker for HPV transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance. Results: HPV DNA was detected in 74% (95% confidence interval (CI): 70-78%) of invasive cancers and in 96% (95% CI: 92-98%) of VAIN 2/3. Among cancers, the highest detection rates were observed in warty-basaloid subtype of squamous cell carcinomas, and in younger ages. Concerning the type-specific distribution, HPV16 was the most frequently type detected in both precancerous and cancerous lesions (59%). p16 INK4a overexpression was found in 87% of HPV DNA positive vaginal cancer cases. Conclusions: HPV was identified in a large proportion of invasive vaginal cancers and in almost all VAIN 2/3. HPV16 was the most common type detected. A large impact in the reduction of the burden of vaginal neoplastic lesions is expected among vaccinated cohorts.
Journal of the Chemical Society, Perkin Transactions 2, 1991
ABSTRACT Crystal structure analysis of salts of one monosubstituted (1) and three peri disubstitu... more ABSTRACT Crystal structure analysis of salts of one monosubstituted (1) and three peri disubstituted naphthalene derivatives (2, 3 and 4) are described. The strong repulsion between the nitrogen lone pairs in neutral structures is replaced by an intramolecular N+-H ... N interaction in compounds 2, 3 and 4 giving rise to a similar distortion in the naphthalene skeleton in each case, an inward bending of the exocyclic C(aryl)-N bonds and a decrease of the N ... N distance: [2.606(4)-2.533(6) angstrom] versus 2.792(3) angstrom found in 1,8-bis(N,N-dimethyl)naphthalene and 2.716(11) and 2.739(10) angstrom in 1,8-diaminonaphthalene. This behaviour is characteristic of proton sponges.
A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII ... more A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII BRITE-EURAM-III-financed project on solar photocatalytic detoxification of water. The project objective was to develop a simple, efficient and commercially competitive water-treatment technology, based on compound parabolic collectors (CPCs) solar collectors and TiO 2 photocatalysis, to make possible easy design and installation. The design, setup and preliminary results of the main project deliverable, the first European industrial solar detoxification treatment plant, is presented. This plant has been designed for the batch treatment of 2 m 3 of water with a 100 m 2 collector-aperture area and aqueous aerated suspensions of polycrystalline TiO 2 irradiated by sunlight. Fully automatic control reduces operation and maintenance manpower. Plant behaviour has been compared (using dichloroacetic acid and cyanide at 50 mg l À1 initial concentration as model compounds) with the small CPC pilot plants installed at the Plataforma Solar de Almer ı ıa several years ago. The first results with high-content cyanide (1 g l À1) waste water are presented and plant treatment capacity is calculated.
... 20] MA Alonso Pardo, \Edici on interactiva en entornos incrementales", Master's the... more ... 20] MA Alonso Pardo, \Edici on interactiva en entornos incrementales", Master's thesis, Computer Sciences Department, University of A Coruña, A ... 22] J. Heering, PRH Hendriks, P. Klint, and J. Rekers, \The syntax de nition formalism sdf - reference manual", SIGPLAN Notices ...
This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a ... more This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide. Methods: We analysed 189 VAIN 2/3 and 408 invasive vaginal cancer cases collected from 31 countries from 1986 to 2011. After histopathological evaluation of sectioned formalin-fixed paraffin-embedded samples, HPV DNA detection and typing was performed using the SPF-10/DNA enzyme immunoassay (DEIA)/LiPA 25 system (version 1). A subset of 146 vaginal cancers was tested for p16 INK4a expression, a cellular surrogate marker for HPV transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance. Results: HPV DNA was detected in 74% (95% confidence interval (CI): 70-78%) of invasive cancers and in 96% (95% CI: 92-98%) of VAIN 2/3. Among cancers, the highest detection rates were observed in warty-basaloid subtype of squamous cell carcinomas, and in younger ages. Concerning the type-specific distribution, HPV16 was the most frequently type detected in both precancerous and cancerous lesions (59%). p16 INK4a overexpression was found in 87% of HPV DNA positive vaginal cancer cases. Conclusions: HPV was identified in a large proportion of invasive vaginal cancers and in almost all VAIN 2/3. HPV16 was the most common type detected. A large impact in the reduction of the burden of vaginal neoplastic lesions is expected among vaccinated cohorts.
Journal of the Chemical Society, Perkin Transactions 2, 1991
ABSTRACT Crystal structure analysis of salts of one monosubstituted (1) and three peri disubstitu... more ABSTRACT Crystal structure analysis of salts of one monosubstituted (1) and three peri disubstituted naphthalene derivatives (2, 3 and 4) are described. The strong repulsion between the nitrogen lone pairs in neutral structures is replaced by an intramolecular N+-H ... N interaction in compounds 2, 3 and 4 giving rise to a similar distortion in the naphthalene skeleton in each case, an inward bending of the exocyclic C(aryl)-N bonds and a decrease of the N ... N distance: [2.606(4)-2.533(6) angstrom] versus 2.792(3) angstrom found in 1,8-bis(N,N-dimethyl)naphthalene and 2.716(11) and 2.739(10) angstrom in 1,8-diaminonaphthalene. This behaviour is characteristic of proton sponges.
A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII ... more A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII BRITE-EURAM-III-financed project on solar photocatalytic detoxification of water. The project objective was to develop a simple, efficient and commercially competitive water-treatment technology, based on compound parabolic collectors (CPCs) solar collectors and TiO 2 photocatalysis, to make possible easy design and installation. The design, setup and preliminary results of the main project deliverable, the first European industrial solar detoxification treatment plant, is presented. This plant has been designed for the batch treatment of 2 m 3 of water with a 100 m 2 collector-aperture area and aqueous aerated suspensions of polycrystalline TiO 2 irradiated by sunlight. Fully automatic control reduces operation and maintenance manpower. Plant behaviour has been compared (using dichloroacetic acid and cyanide at 50 mg l À1 initial concentration as model compounds) with the small CPC pilot plants installed at the Plataforma Solar de Almer ı ıa several years ago. The first results with high-content cyanide (1 g l À1) waste water are presented and plant treatment capacity is calculated.
... 20] MA Alonso Pardo, \Edici on interactiva en entornos incrementales", Master's the... more ... 20] MA Alonso Pardo, \Edici on interactiva en entornos incrementales", Master's thesis, Computer Sciences Department, University of A Coruña, A ... 22] J. Heering, PRH Hendriks, P. Klint, and J. Rekers, \The syntax de nition formalism sdf - reference manual", SIGPLAN Notices ...
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