Pages that link to "Q42426620"

The following pages link to BMS-708,163 targets presenilin and lacks notch-sparing activity (Q42426620):

Displaying 36 items.

• γ-Secretase inhibitors and modulators (Q26830462) (← links)
• Toward the structure of presenilin/γ-secretase and presenilin homologs (Q27002018) (← links)
• Amyloid-β and APP deficiencies cause severe cerebrovascular defects: important work for an old villain (Q27305806) (← links)
• A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP (Q27314017) (← links)
• HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B (Q28551145) (← links)
• γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase (Q33704474) (← links)
• Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials (Q34014237) (← links)
• γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells (Q35071626) (← links)
• γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin (Q36742200) (← links)
• A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay (Q36875846) (← links)
• The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease (Q37474466) (← links)
• Development and mechanism of γ-secretase modulators for Alzheimer's disease (Q38101383) (← links)
• Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012. (Q38123209) (← links)
• Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution. (Q38433126) (← links)
• Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology (Q38618862) (← links)
• Inhibition of γ-Secretase Leads to an Increase in Presenilin-1. (Q38641308) (← links)
• γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct (Q38766437) (← links)
• The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind (Q38769710) (← links)
• Intramembrane proteases as drug targets (Q38790377) (← links)
• Physiological and pathological roles of the γ-secretase complex (Q38822512) (← links)
• γ-Secretase Modulators and Inhibitors Induce Different Conformational Changes of Presenilin 1 Revealed by FLIM and FRET. (Q38832923) (← links)
• Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease (Q38850493) (← links)
• Unlocking truths of γ-secretase in Alzheimer's disease: what is the translational potential? (Q39285976) (← links)
• Emerging amyloid and tau targeting treatments for Alzheimer's disease (Q39296311) (← links)
• Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase (Q39715922) (← links)
• Development of CBAP-BPyne, a probe for γ-secretase and presenilinase (Q40396092) (← links)
• A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human (Q42621620) (← links)
• M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory (Q46956989) (← links)
• Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes (Q50352138) (← links)
• Structural and Chemical Biology of Presenilin Complexes (Q51093204) (← links)
• Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects. (Q53459259) (← links)
• BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease (Q64077439) (← links)
• γ-Secretase and its modulators: Twenty years and beyond (Q91581374) (← links)
• Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase (Q92932113) (← links)
• Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution (Q92948317) (← links)
• The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease (Q98906938) (← links)