Pages that link to "Q36288687"
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The following pages link to Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis (Q36288687):
Displaying 50 items.
- BCL2 antagonist/killer 1 (Q4875407) (← links)
- MCL1 apoptosis regulator, BCL2 family member (Q21112678) (← links)
- Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1 (Q22001533) (← links)
- ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death (Q24296645) (← links)
- Heterodimerization of BAK and MCL-1 activated by detergent micelles (Q24305060) (← links)
- Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy (Q24635408) (← links)
- Small-molecule Bcl-2 antagonists as targeted therapy in oncology (Q24646161) (← links)
- Regulation of Bim in Health and Disease (Q26781203) (← links)
- Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents (Q26800890) (← links)
- Bcl-2 antagonists: a proof of concept for CLL therapy (Q26823996) (← links)
- Melanoma: new insights and new therapies (Q26853127) (← links)
- Targeting BCL2-Proteins for the Treatment of Solid Tumours (Q26853686) (← links)
- Targeting the Bcl-2 family for cancer therapy (Q26866936) (← links)
- BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore (Q27002044) (← links)
- The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics (Q27010154) (← links)
- Targeting Mcl-1 for the therapy of cancer (Q27011870) (← links)
- The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization (Q27318794) (← links)
- Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations (Q27321588) (← links)
- Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands (Q27657282) (← links)
- The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer (Q27662487) (← links)
- Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agents (Q28075606) (← links)
- Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells (Q28484403) (← links)
- An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI) (Q28485864) (← links)
- BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components (Q28486502) (← links)
- Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells (Q28534817) (← links)
- Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts (Q28538631) (← links)
- Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells (Q28540339) (← links)
- Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations (Q28543593) (← links)
- Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain (Q30437957) (← links)
- Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection (Q30448355) (← links)
- A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. (Q30466831) (← links)
- Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia (Q30538418) (← links)
- A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival (Q31100573) (← links)
- Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains (Q33363105) (← links)
- Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia (Q33381678) (← links)
- Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity (Q33392920) (← links)
- Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition (Q33407258) (← links)
- A phase I/II study of the pan Bcl-2 inhibitor obatoclax mesylate plus bortezomib for relapsed or refractory mantle cell lymphoma (Q33414307) (← links)
- BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. (Q33727248) (← links)
- Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance (Q33755338) (← links)
- Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed (Q33780816) (← links)
- Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival (Q33797357) (← links)
- Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells (Q33808800) (← links)
- Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. (Q33839850) (← links)
- Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis (Q33851111) (← links)
- Discovery and Development of Thiazolo[3,2‐a]pyrimidinone Derivatives as General Inhibitors of Bcl‐2 Family Proteins (Q33882002) (← links)
- New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer (Q33920494) (← links)
- Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy (Q34004454) (← links)
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL (Q34046604) (← links)
- Effect of a small molecule BCL-2 inhibitor on immune function and use with a recombinant vaccine (Q34074715) (← links)