The Structure and Function of DNA G-Quadruplexes (Q99408946)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32923997%20AND%20SRC:MED&resulttype=core&format=json

17 September 2020

title

The Structure and Function of DNA G-Quadruplexes (English)

1 reference

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17 September 2020

author name string

Jochen Spiegel

series ordinal

1

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17 September 2020

Santosh Adhikari

series ordinal

2

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17 September 2020

Shankar Balasubramanian

series ordinal

3

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17 September 2020

publication date

1 February 2020

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17 September 2020

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17 September 2020

volume

2

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17 September 2020

issue

2

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17 September 2020

page(s)

123-136

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Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

17 September 2020

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Confined space facilitates G-quadruplex formation

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Cytosine-cytosine+ base pairing stabilizes DNA quadruplexes and cytosine methylation greatly enhances the effect

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Quadruplex Nucleic Acids as Novel Therapeutic Targets

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

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Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.

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Genome-wide localization of small molecules

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Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

7 January 2021

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The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

7 January 2021

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Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs

7 January 2021

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Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells

7 January 2021

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7 January 2021

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G-quadruplexes in promoters throughout the human genome

7 January 2021

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In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

7 January 2021

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Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates.

7 January 2021

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Quantitative visualization of DNA G-quadruplex structures in human cells

7 January 2021

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Detection of G-quadruplex DNA in mammalian cells

7 January 2021

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Telomeric G-quadruplexes are a substrate and site of localization for human telomerase

7 January 2021

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Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres

7 January 2021

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Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues

7 January 2021

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Preferential binding of a G-quadruplex ligand to human chromosome ends.

7 January 2021

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Small-molecule-induced DNA damage identifies alternative DNA structures in human genes

7 January 2021

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Copper-Alkyne Complexation Responsible for the Nucleolar Localization of Quadruplex Nucleic Acid Drugs Labeled by Click Reactions

7 January 2021

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The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy

7 January 2021

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Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe.

7 January 2021

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7 January 2021

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ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

7 January 2021

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G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD.

7 January 2021

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Rif1 binds to G quadruplexes and suppresses replication over long distances.

7 January 2021

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DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

7 January 2021

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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

7 January 2021

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Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome

7 January 2021

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G-quadruplex structures mark human regulatory chromatin

7 January 2021

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Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing.

7 January 2021

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G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins.

7 January 2021

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Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

7 January 2021

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Identification of novel interactors of human telomeric G-quadruplex DNA

7 January 2021

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Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.

7 January 2021

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Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein

7 January 2021

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A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro.

7 January 2021

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The Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors

7 January 2021

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Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions

7 January 2021

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Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry.

7 January 2021

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G-quadruplex unwinding helicases and their function in vivo

7 January 2021

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Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases

7 January 2021

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A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

7 January 2021

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Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

7 January 2021

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Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model

7 January 2021

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Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro

7 January 2021

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Human replication protein A unfolds telomeric G-quadruplexes

7 January 2021

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Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.

7 January 2021

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Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

7 January 2021

1 reference

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The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element

7 January 2021

1 reference

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Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

7 January 2021

1 reference

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HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

7 January 2021

1 reference

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DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro.

7 January 2021

1 reference

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DNA G-quadruplex structures mold the DNA methylome

7 January 2021

1 reference

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CpG Methylation Changes G-Quadruplex Structures Derived from Gene Promoters and Interaction with VEGF and SP1

7 January 2021

1 reference

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Expression of the human telomerase reverse transcriptase gene is modulated by quadruplex formation in its first exon due to DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

7 January 2021

1 reference

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A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.

7 January 2021

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DNA damage processing at telomeres: The ends justify the means.

7 January 2021

1 reference

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RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Inhibition of telomerase by G-quartet DNA structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Pif1 family helicases suppress genome instability at G-quadruplex motifs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures

7 January 2021

2 references

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7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Impact of Oxidative Lesions on the Human Telomeric G-Quadruplex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

G-Quadruplexes in DNA Replication: A Problem or a Necessity?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Replication of G Quadruplex DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

G-quadruplex-induced instability during leading-strand replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Local epigenetic reprogramming induced by G-quadruplex ligands

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

i-Motif DNA: structural features and significance to cell biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

I-motif DNA structures are formed in the nuclei of human cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Mutually Exclusive Formation of G-Quadruplex and i-Motif Is a General Phenomenon Governed by Steric Hindrance in Duplex DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

The dynamic response of upstream DNA to transcription-generated torsional stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECHM.2019.07.002

10.1016/J.TRECHM.2019.07.002

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32923997%20AND%20SRC:MED&resulttype=core&format=json

17 September 2020

1 reference