Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity (Q90663348)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31604989%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

title

Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity (English)

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15 April 2020

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R Thiagarajan

1

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15 April 2020

M K N Sai Varsha

2

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15 April 2020

V Srinivasan

3

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15 April 2020

R Ravichandran

4

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15 April 2020

K Saraboji

5

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15 April 2020

publication date

11 October 2019

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15 April 2020

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15 April 2020

volume

9

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15 April 2020

issue

1

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15 April 2020

page(s)

14684

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Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor

15 April 2020

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Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo

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7 January 2021

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Aldose reductase inhibitors zopolrestat and ferulic acid alleviate hypertension associated with diabetes: effect on vascular reactivity

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Inhibition of aldose reductase activates hepatic peroxisome proliferator-activated receptor-α and ameliorates hepatosteatosis in diabetic db/db mice.

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Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in alloxan-diabetic rats

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Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats

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Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats

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High glucose enhances IL-1beta-induced cyclooxygenase-2 expression in rat vascular smooth muscle cells

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Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis

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Confirmation of danofloxacin residues in chicken and cattle liver by microbore high-performance liquid chromatography electrospray ionization tandem mass spectrometry

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7 January 2021

Pharmacokinetics of zopolrestat, a carboxylic acid aldose reductase inhibitor, in normal and diabetic rats

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7 January 2021

Pharmacokinetics of the aldose reductase inhibitor, zopolrestat, in humans

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7 January 2021

Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration

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7 January 2021

Zopolrestat Induced Suicidal Death of Human Erythrocytes

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7 January 2021

Comparative effects of vitamin K2 and estradiol on experimental arteriosclerosis with diabetes mellitus

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7 January 2021

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7 January 2021

Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review

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Vitamin K2 Prevents Hyperglycemia and Cancellous Osteopenia in Rats with Streptozotocin-Induced Type 1 Diabetes

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7 January 2021

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7 January 2021

Matrix Gla protein species and risk of cardiovascular events in type 2 diabetic patients

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7 January 2021

The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial

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7 January 2021

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Vitamin K1 alleviates streptozotocin-induced type 1 diabetes by mitigating free radical stress, as well as inhibiting NF-κB activation and iNOS expression in rat pancreas.

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation

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7 January 2021

Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners

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7 January 2021

Role of aldose reductase and sorbitol in maintaining the medullary intracellular milieu

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7 January 2021

Molecular cloning of testicular 20 alpha-hydroxysteroid dehydrogenase: identity with aldose reductase.

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7 January 2021

Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model.

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7 January 2021

Contributions of polyol pathway to oxidative stress in diabetic cataract.

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7 January 2021

Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens

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7 January 2021

Aldose reductase deficiency protects sugar-induced lens opacification in rats

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7 January 2021

The increase in lipid peroxidation in diabetic rat lens can be reversed by oral sorbinil

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7 January 2021

Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options

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7 January 2021

Aldose reductase inhibitors: therapeutic implications for diabetic complications

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7 January 2021

Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs

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7 January 2021

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7 January 2021

Inhibitory effects of Colocasia esculenta (L.) Schott constituents on aldose reductase

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7 January 2021

Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications

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12 December 2020

Aldose reductase-catalyzed reduction of acrolein: implications in cyclophosphamide toxicity

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12 December 2020

Tissue distribution and biotransformation of zopolrestat, an aldose reductase inhibitor, in rats

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12 December 2020

Protein measurement with the Folin phenol reagent

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12 December 2020

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.

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12 December 2020

[Diabetes mellitus and osteoporosis. Dietary therapy of diabetes related osteoporosis]

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12 December 2020

Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk.

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12 December 2020

Aldose reductase, ocular diabetic complications and the development of topical Kinostat(®).

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12 December 2020

10.1038/S41598-019-51059-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31604989%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31604989%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

PubMed publication ID

31604989

1 reference