Next-generation regulatory T cell therapy (Q90197782)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

review article

1 reference

title

Next-generation regulatory T cell therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Jeffrey A Bluestone

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

Qizhi Tang

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

author name string

Yannick D Muller

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

publication date

20 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

12 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

page(s)

749-769

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

Autoimmune Polyendocrine Syndromes

12 April 2020

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7 January 2021

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

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7 January 2021

Emerging Functions of Regulatory T Cells in Tissue Homeostasis.

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7 January 2021

Continuous requirement for the TCR in regulatory T cell function

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7 January 2021

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

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7 January 2021

Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity.

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7 January 2021

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

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7 January 2021

TCR affinity and specificity requirements for human regulatory T-cell function

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7 January 2021

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

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7 January 2021

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

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7 January 2021

Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling

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7 January 2021

Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children

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7 January 2021

Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer

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7 January 2021

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

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7 January 2021

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

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7 January 2021

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues

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7 January 2021

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

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7 January 2021

FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance

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7 January 2021

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

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7 January 2021

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer

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7 January 2021

Helios Enhances Treg Cell Function in Cooperation With FoxP3.

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7 January 2021

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

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7 January 2021

Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production.

1 reference

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7 January 2021

Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.

1 reference

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7 January 2021

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

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7 January 2021

Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1.

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7 January 2021

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

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7 January 2021

Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice

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7 January 2021

Generation of human islet-specific regulatory T cells by TCR gene transfer

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7 January 2021

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

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7 January 2021

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

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7 January 2021

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

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7 January 2021

Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes

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7 January 2021

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

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7 January 2021

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

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7 January 2021

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy

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7 January 2021

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

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7 January 2021

Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor

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7 January 2021

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Regulatory T-cell therapy for transplantation: how many cells do we need?

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Expansion of human regulatory T-cells from patients with type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD28 costimulation is essential for human T regulatory expansion and function

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

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7 January 2021

T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development

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7 January 2021

Epigenetic quantification of tumor-infiltrating T-lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Regulatory T-cell therapy in transplantation: moving to the clinic

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Interleukin 2 signaling is required for CD4(+) regulatory T cell function

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Therapeutic window of interleukin-2 for autoimmune diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Interleukin-2 and regulatory T cells in graft-versus-host disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Impact of Immune-Modulatory Drugs on Regulatory T Cell

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Transplant trials with Tregs: perils and promises

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Ex vivo expanded natural regulatory T cells from patients with end-stage renal disease or kidney transplantation are useful for autologous cell therapy

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CAR T Cells with Enhanced Sensitivity to B Cell Maturation Antigen for the Targeting of B Cell Non-Hodgkin's Lymphoma and Multiple Myeloma

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Projection of an immunological self shadow within the thymus by the aire protein

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Citrullination and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Diabetogenic T-cell clones recognize an altered peptide of chromogranin A.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

T cell epitopes and post-translationally modified epitopes in type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Immune homeostasis enforced by co-localized effector and regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Revealing the specificity of regulatory T cells in murine autoimmune diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

High-throughput pairing of T cell receptor α and β sequences

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Identifying specificity groups in the T cell receptor repertoire

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Quantifiable predictive features define epitope-specific T cell receptor repertoires

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Transfer of specificity by murine alpha and beta T-cell receptor genes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Facilitating matched pairing and expression of TCR chains introduced into human T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Selected murine residues endow human TCR with enhanced tumor recognition

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Reprogramming human T cell function and specificity with non-viral genome targeting

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

TCRs genetically linked to CD28 and CD3ε do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A TCR-based Chimeric Antigen Receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Heterogeneous expression of carcinoembryonic antigen in the normal colon and upregulation in active ulcerative colitis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

In vivoInhibition of Human CD19-Targeted Effector T Cells by Natural T Regulatory Cells in a Xenotransplant Murine Model of B Cell Malignancy

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Generating Antigen-Specific Regulatory T Cells in the Fast Lane.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Efficient and selective prevention of GVHD by antigen-specific induced Tregs via linked-suppression in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

The past and future of haemophilia: diagnosis, treatments, and its complications.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Antibodies against citrullinated vimentin in rheumatoid arthritis: higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

The pharmacology of second-generation chimeric antigen receptors.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Engrafting human regulatory T cells with a flexible modular chimeric antigen receptor technology.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Chimeric antigen receptor costimulation domains modulate human regulatory T cell function.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Rewiring T-cell responses to soluble factors with chimeric antigen receptors.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Reversal of tumor immune inhibition using a chimeric cytokine receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Development and applications of CRISPR-Cas9 for genome engineering

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Editing DNA Methylation in the Mammalian Genome

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Clinical use of lentiviral vectors.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Gene therapy for neurological disorders: progress and prospects

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CRISPR/Cas9 genome editing in human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Transcription factor Foxp3 and its protein partners form a complex regulatory network

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

An essential role for the IL-2 receptor in Treg cell function

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

'Repair' Treg Cells in Tissue Injury

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A Distinct Function of Regulatory T Cells in Tissue Protection

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Generation of hypoimmunogenic human pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Engineered T Regulatory Type 1 Cells for Clinical Application.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Methods for in vitro generation of human type 1 regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/- Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A unique subset of self-specific intraintestinal T cells maintains gut integrity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Regulation of immunity by a novel population of Qa-1-restricted CD8alphaalpha+TCRalphabeta+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Regulatory B cells: origin, phenotype, and function.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

B-cell suppression of delayed hypersensitivity reactions

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

B cells regulate autoimmunity by provision of IL-10.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Nonresolving inflammation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

CD4+CD25high regulatory cells in human peripheral blood

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

An essential role for Scurfin in CD4+CD25+ T regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Direct observation of ligand recognition by T cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Target antigen density governs the efficacy of anti-CD20-CD28-CD3 ζ chimeric antigen receptor-modified effector CD8+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs).

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase.

1 reference

https://api.crossref.org/works/10.1038%2FS41573-019-0041-4

7 January 2021

1 reference

12 December 2020

Cell interactions in the induction of tolerance: the role of thymic lymphocytes

1 reference

12 December 2020

Infectious immunological tolerance

1 reference

12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

12 December 2020

Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection

1 reference

12 December 2020

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.

1 reference

12 December 2020

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

1 reference

12 December 2020

Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes

1 reference

12 December 2020

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

1 reference

12 December 2020

c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice

1 reference

12 December 2020

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants.

1 reference

12 December 2020

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells

1 reference

12 December 2020

10.1038/S41573-019-0041-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31541224%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

1 reference