Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri (Q89873488)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

Tupaia belangeri

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

author name string

Juan D Rodriguez-Callejas

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Eberhard Fuchs

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

publication date

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

9 April 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Ferritins: a family of molecules for iron storage, antioxidation and more.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Tau phosphorylation, aggregation, and cell toxicity

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Autotaxin protects microglial cells against oxidative stress.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Heterozygous TREM2 mutations in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Neuropathological stageing of Alzheimer-related changes

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Tau protein binds to microtubules through a flexible array of distributed weak sites

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Inflammation, microglia, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

The tree shrews: adjuncts and alternatives to primates as models for biomedical research

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Mineralization in ferritin: an efficient means of iron storage

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Glutathione levels in primary glial cultures: monochlorobimane provides evidence of cell type-specific distribution

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Effect of aging on the microglial response to peripheral nerve injury

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Isoforms of ferritin have a specific cellular distribution in the brain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Cellular management of iron in the brain.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Iron accumulation in aging: modulation by dietary restriction

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Amyloid Beta1-42 and the Phoshorylated Tau Threonine 231 in Brains of Aged Cynomolgus Monkeys (Macaca fascicularis).

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Iron and aluminium in relation to brain ferritin in normal individuals and Alzheimer's-disease and chronic renal-dialysis patients

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Genome of the Chinese tree shrew

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Does the Genetic Feature of the Chinese Tree Shrew (Tupaia belangeri chinensis) Support Its Potential as a Viable Model for Alzheimer's Disease Research?

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Alternatively activated microglia and macrophages in the central nervous system.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Tree shrews at the German Primate Center

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Postmortem changes in the phosphorylation state of tau-protein in the rat brain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Aging dependent effect of nuclear tau.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Alternative activation of macrophages

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates α-synuclein expression

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

TREM2 Variants in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Does oxidative damage to DNA increase with age?

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Abnormally phosphorylated protein tau in the cortex of aged individuals of various mammalian orders.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

The microglial sensome revealed by direct RNA sequencing

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Dual role of superoxide dismutase 2 induced in activated microglia: oxidative stress tolerance and convergence of inflammatory responses.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglia: Housekeeper of the Central Nervous System.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Preservation of hippocampal neuron numbers and hippocampal subfield volumes in behaviorally characterized aged tree shrews.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Aging is accompanied by a subfield-specific reduction of serotonergic fibers in the tree shrew hippocampal formation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

A cytoarchitectonic study of the hippocampal formation of the tree shrew (Tupaia belangeri).

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Whole-brain metallomic analysis of the common marmoset (Callithrix jacchus).

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Hemin-Enhanced Resistance of Human Leukemia Cells to Oxidative Killing: Antisense Determination of Ferritin Involvement

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Phosphorylation and Dephosphorylation of Tau Protein During Synthetic Torpor.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Iron accumulation and lipid peroxidation in aging C57BL/6J mice

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Regulation of alpha(2A)-adrenoceptor expression by chronic stress in neurons of the brain stem

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Cloning of glucocorticoid receptor and mineralocorticoid receptor cDNA and gene expression in the central nervous system of the tree shrew (Tupaia belangeri)

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Sex differences in microglial phagocytosis in the neonatal hippocampus

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Review: microglia of the aged brain: primed to be activated and resistant to regulation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglial M1/M2 polarization and metabolic states

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Ferritin and the response to oxidative stress

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Isolation and pharmacological characterization of two functional splice variants of corticotropin-releasing factor type 2 receptor from Tupaia belangeri

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Corticotropin-releasing factor receptor type 1 from Tupaia belangeri--cloning, functional expression and tissue distribution

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Primate-like amyloid-beta sequence but no cerebral amyloidosis in aged tree shrews

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Brain iron deposits are associated with general cognitive ability and cognitive aging

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Effects of aging on the neuroglial cells and pericytes within area 17 of the rhesus monkey cerebral cortex

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Iron levels in the human brain: a post-mortem study of anatomical region differences and age-related changes

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Loss of ferritin-positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Characterization of plasma thiol redox potential in a common marmoset model of aging.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

A simple solution for antibody signal enhancement in immunofluorescence and triple immunogold assays

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue: Application in the APP/PS1 Mouse Model of Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Alzheimer's disease pathology in Nasu-Hakola disease brains

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Axonal transport and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglial senescence: does the brain's immune system have an expiration date?

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Dystrophic microglia in the aging human brain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglia in dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

https://api.crossref.org/works/10.1002%2FGLIA.23804

1 reference

7 January 2021

Multimarker screening of oxidative stress in aging.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

The role of microglia in the healthy brain.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglia and the Development of Spongiform Change in Creutzfeldt-Jakob Disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglia/macrophage polarization dynamics in white matter after traumatic brain injury

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

The role of iron in brain ageing and neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Alpha-synuclein is highly prone to distribution in the hippocampus and midbrain in tree shrews, and its fibrils seed Lewy body-like pathology in primary neurons

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Microglial pathology in Down syndrome

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Amyloid Beta (Aβ) Protein- and Amyloid Precursor Protein (APP)- Immunoreactive Structures in the Brains of Aged Tree Shrews

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Somatostatin‐immunoreactive senile plaque‐like structures in the frontal cortex and nucleus accumbens of aged tree shrews and Japanese macaques

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Cellular iron status influences the functional relationship between microglia and oligodendrocytes

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Sequential phosphorylation of Tau by glycogen synthase kinase‐3β and protein kinase A at Thr212 and Ser214 generates the Alzheimer‐specific epitope of antibody AT100 and requires a paired‐helical‐filament‐like conformation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.23804

7 January 2021

Identifiers

DOI

10.1002/GLIA.23804

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32096580%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference