The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade (Q89712904)

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8 April 2020

title

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade (English)

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8 April 2020

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5

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27 May 2020

author name string

B Coutard

1

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27 May 2020

C Valle

2

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27 May 2020

X de Lamballerie

3

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27 May 2020

B Canard

4

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27 May 2020

E Decroly

6

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27 May 2020

publication date

10 February 2020

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8 April 2020

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27 May 2020

volume

176

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27 May 2020

page(s)

104742

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On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain

27 May 2020

cites work

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12 December 2020

Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

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12 December 2020

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant

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12 December 2020

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

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12 December 2020

Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours

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12 December 2020

Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus

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12 December 2020

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

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12 December 2020

Maturation of HIV envelope glycoprotein precursors by cellular endoproteases

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12 December 2020

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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12 December 2020

Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus

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12 December 2020

Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection

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12 December 2020

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

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12 December 2020

Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide

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12 December 2020

Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection.

1 reference

12 December 2020

Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus

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12 December 2020

Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.

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12 December 2020

Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure

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12 December 2020

The biology and therapeutic targeting of the proprotein convertases

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12 December 2020

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

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12 December 2020

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

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12 December 2020

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

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12 December 2020

Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond

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12 December 2020

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder

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12 December 2020

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

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12 December 2020

SARS and MERS: recent insights into emerging coronaviruses

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12 December 2020

Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth

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12 December 2020

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

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12 December 2020

Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

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12 December 2020

Furin-mediated protein processing in infectious diseases and cancer

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12 December 2020

The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases

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12 December 2020

The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism

1 reference

12 December 2020

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

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12 December 2020

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

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12 December 2020

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

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12 December 2020

Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak

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12 December 2020

10.1016/J.ANTIVIRAL.2020.104742

Identifiers

DOI

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Dimensions Publication ID

27 May 2020

COVIDWHO ID

covidwho-624

0 references

1124775726

1 reference

Dimensions COVID-19 publications, datasets and clinical trials

28 May 2020

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27 May 2020

PubMed publication ID

32057769

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