Phosphatase and tensin homologue: a therapeutic target for SMA (Q89700534)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29263925%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

review article

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title

Phosphatase and tensin homologue: a therapeutic target for SMA (English)

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7 April 2020

2

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7 April 2020

author name string

Vinay K Godena

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29263925%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

publication date

8 September 2017

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7 April 2020

volume

2

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7 April 2020

page(s)

17038

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Creative Commons Attribution 4.0 International

7 April 2020

copyright license

start time

8 September 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Chronic generalized spinal muscular atrophy of infancy and childhood. Arrested Werdnig-Hoffman disease

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Correlation between severity and SMN protein level in spinal muscular atrophy

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7 January 2021

Newborn and carrier screening for spinal muscular atrophy

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7 January 2021

Linkage mapping of the spinal muscular atrophy gene

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Sequence-specific interaction of U1 snRNA with the SMN complex

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly

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7 January 2021

Expression of the SMN Gene, the Spinal Muscular Atrophy Determining Gene, in the Mammalian Central Nervous System

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7 January 2021

Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization.

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7 January 2021

Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons

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7 January 2021

Identification and characterization of a spinal muscular atrophy-determining gene

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7 January 2021

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

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7 January 2021

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

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7 January 2021

Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector.

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

cDNA isolation, expression, and chromosomal localization of the mouse survival motor neuron gene (Smn).

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

A mouse model for spinal muscular atrophy

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

A critical smn threshold in mice dictates onset of an intermediate spinal muscular atrophy phenotype associated with a distinct neuromuscular junction pathology.

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy

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7 January 2021

Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Knockdown of SMN by RNA interference induces apoptosis in differentiated P19 neural stem cells.

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Is spinal muscular atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Spinal muscular atrophy: going beyond the motor neuron

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Astrocytes influence the severity of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Reduced expression of nicotinic AChRs in myotubes from spinal muscular atrophy I patients.

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Digital necroses and vascular thrombosis in severe spinal muscular atrophy

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7 January 2021

Glucose metabolism and pancreatic defects in spinal muscular atrophy

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

The use of mechanical ventilation is appropriate in children with genetically proven spinal muscular atrophy type 1: the motion for.

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Fatty acid oxidation abnormalities in childhood-onset spinal muscular atrophy: primary or secondary defect(s)?

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https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Severe spinal muscular atrophy variant associated with congenital bone fractures.

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Bone loss in survival motor neuron (Smn(-/-) SMN2) genetic mouse model of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy.

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

A role for nuclear PTEN in neuronal differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Regulation of PTEN transcription by p53

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN: a crucial mediator of mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

The integrin alpha6beta1 modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Ubiquitination regulates PTEN nuclear import and tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells.

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene

1 reference

https://api.crossref.org/works/10.1038%2FSIGTRANS.2017.38

7 January 2021

Segregation analysis of chronic childhood spinal muscular atrophy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29263925

12 December 2020

inferred from PubMed ID database lookup

Genetic inhibition of JNK3 ameliorates spinal muscular atrophy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29263925

12 December 2020

inferred from PubMed ID database lookup

Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29263925

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/SIGTRANS.2017.38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29263925%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29263925%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

PubMed publication ID

29263925

1 reference