Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score (Q89553680)

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scientific article published on 11 March 2020

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English	Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score	scientific article published on 11 March 2020

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scholarly article

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6 April 2020

Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score (English)

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6 April 2020

genetic variation

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Keith Owen Yeates

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Keith Owen Yeates

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6 April 2020

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Amery Treble-Barna

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6 April 2020

Valentina Pilipenko

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6 April 2020

Shari L Wade

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6 April 2020

Anil G Jegga

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6 April 2020

H Gerry Taylor

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6 April 2020

Lisa J Martin

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6 April 2020

Brad G Kurowski

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6 April 2020

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11 March 2020

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6 April 2020

Journal of Neurotrauma

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PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32024452%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Assessment of coma and impaired consciousness. A practical scale

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of recovery from traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Childhood traumatic brain injury: neuropsychological status at the time of hospital discharge.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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A Modification of the Injury Severity Score That Both Improves Accuracy and Simplifies Scoring

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https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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GRR: graphical representation of relationship errors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predictors of outcome following traumatic brain injury in young children

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Role of genotype in the cycle of violence in maltreated children

1 reference

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12 December 2020

based on heuristic

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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

1 reference

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12 December 2020

based on heuristic

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Attention deficit hyperactivity disorder in children and adolescents following traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Generating genetic risk scores from intermediate phenotypes for use in association studies of clinically significant endpoints

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Closed head injury--an inflammatory disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Association between interleukin-1 beta (IL-1beta) gene polymorphism and outcome after head injury: an early report

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Modulation of glial cell functions by adenosine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Multiplex Assessment of Cytokine and Chemokine Levels in Cerebrospinal Fluid following Severe Pediatric Traumatic Brain Injury: Effects of Moderate Hypothermia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 and nerve growth factor upregulation correlates with improved outcome in children with severe traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecto-5'-nucleotidase: Structure function relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of traumatic brain injury for targeted therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Traumatic brain injury in young children: postacute effects on cognitive and school readiness skills

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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The family environment as a moderator of psychosocial outcomes following traumatic brain injury in young children

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting sensation seeking from dopamine genes. A candidate-system approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of microglia in neurotrauma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-Environment Interaction in Psychological Traits and Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship of parental warm responsiveness and negativity to emerging behavior problems following traumatic brain injury in young children

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 polymorphism associated with fatal outcome in patients with severe traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recommendations for the use of common outcome measures in pediatric traumatic brain injury research.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of BDNF polymorphisms on brain function and behavior in health and disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parenting style is related to executive dysfunction after brain injury in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caregiver ratings of long-term executive dysfunction and attention problems after early childhood traumatic brain injury: family functioning is important

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Essential Role of Psychosocial Risk and Protective Factors in Pediatric Traumatic Brain Injury Research

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

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Predictors of relapse in a bupropion trial for smoking cessation in recently-abstinent alcoholics: preliminary results using an aggregate genetic risk score

1 reference

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12 December 2020

based on heuristic

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Power and predictive accuracy of polygenic risk scores.

1 reference

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12 December 2020

based on heuristic

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Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine gene polymorphisms and outcome after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain inflammation and microglia: facts and misconceptions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maternal warm responsiveness and negativity following traumatic brain injury in young children

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general framework for estimating the relative pathogenicity of human genetic variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of interleukin-6, -8 and -10 are associated with fatal outcome following severe traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic Inflammation After Severe Traumatic Brain Injury: Characterization and Associations With Outcome at 6 and 12 Months Postinjury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploratory associations with tumor necrosis factor-α, disinhibition and suicidal endorsement after traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation in the BDNF gene interacts with age to predict mortality in a prospective, longitudinal cohort with severe TBI.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Research review: Polygenic methods and their application to psychiatric traits

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic programming by early-life stress: Evidence from human populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute CSF interleukin-6 trajectories after TBI: associations with neuroinflammation, polytrauma, and outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting outcome after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of traumatic brain injury: past, present, and future

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence and predictors of externalizing behavior in young adult survivors of pediatric traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of apolipoprotein E episilon (ε)-4 allele on outcome following traumatic brain injury: A systematic review

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury-Related Mortality: Interrelationships Between Genetics and Acute Systemic and Central Nervous System BDNF Profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of angiotensin-converting enzyme tag single nucleotide polymorphisms on the outcome of patients with traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Social problem-solving and social adjustment in paediatric traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Association Between Apolipoprotein E and Functional Outcome After Traumatic Brain Injury: A Meta-Analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Dopamine Pathway Gene Risk Score for Cognitive Recovery Following Traumatic Brain Injury: Methodological Considerations, Preliminary Findings, and Interactions With Sex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principal components derived from CSF inflammatory profiles predict outcome in survivors after severe traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Social Environmental Moderators of Long-term Functional Outcomes of Early Childhood Brain Injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-Term Neuropsychological Profiles and Their Role as Mediators of Adaptive Functioning after Traumatic Brain Injury in Early Childhood

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of cerebrospinal fluid inflammatory biomarkers and relationship to 6-month neurologic outcome in adult severe traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recovery Trajectories of Executive Functioning After Pediatric TBI: A Latent Class Growth Modeling Analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does Apolipoprotein e4 Status Moderate the Association of Family Environment with Long-Term Child Functioning following Early Moderate to Severe Traumatic Brain Injury? A Preliminary Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic regulation of cognition: A circumscribed review of the field

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Observed parent behaviors as time-varying moderators of problem behaviors following traumatic brain injury in young children

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The far-reaching scope of neuroinflammation after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Applying Systems Biology Methodology To Identify Genetic Factors Possibly Associated with Recovery after Traumatic Brain Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of Dopamine-Related Genes on Neurobehavioral Recovery after Traumatic Brain Injury during Early Childhood

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The family environment predicts long-term academic achievement and classroom behavior following traumatic brain injury in early childhood.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of interleukin-1beta polymorphisms on brain function and behavior in healthy and psychiatric disease conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term classroom functioning and its association with neuropsychological and academic performance following traumatic brain injury during early childhood.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Home Environment as a Predictor of Long-Term Executive Functioning following Early Childhood Traumatic Brain Injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychosocial and Executive Function Recovery Trajectories One Year after Pediatric Traumatic Brain Injury: The Influence of Age and Injury Severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secondary Attention-Deficit/Hyperactivity Disorder in Children and Adolescents 5 to 10 Years After Traumatic Brain Injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polygenic risk for psychiatric disorders correlates with executive function in typical development

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The moderating effect of ANKK1 on the association of family environment with longitudinal executive function following traumatic brain injury in early childhood: A preliminary study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in psychiatric disorders: what comes first?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TBI Rehabilomics Research: Conceptualizing a humoral triad for designing effective rehabilitation interventions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parenting styles as a predictor of long-term psychosocial outcomes after traumatic brain injury (TBI) in early childhood

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unraveling the Association between Pediatric Traumatic Brain Injury and Social Dysfunction: The Mediating Role of Self-Regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Tilted Axis: Maladaptive Inflammation and HPA Axis Dysfunction Contribute to Consequences of TBI

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of Secondary ADHD on Long-Term Outcomes After Early Childhood Traumatic Brain Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32024452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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