A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes (Q89464714)

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5 April 2020

title

A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes (English)

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5 April 2020

5

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5 April 2020

author name string

Samantha Ebersoll

1

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5 April 2020

Marta Bogacz

2

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5 April 2020

Lina M Günter

3

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5 April 2020

Tobias P Dick

4

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5 April 2020

publication date

31 January 2020

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5 April 2020

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5 April 2020

volume

9

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Metabolism and functions of trypanothione in the Kinetoplastida

5 April 2020

cites work

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A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi

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A second class of peroxidases linked to the trypanothione metabolism

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The trypanothione-thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity

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Kinetics and Redox-Sensitive Oligomerisation Reveal Negative Subunit Cooperativity in Tryparedoxin Peroxidase of Trypanosoma brucei brucei

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Redox-sensitive GFP in Arabidopsis thaliana is a quantitative biosensor for the redox potential of the cellular glutathione redox buffer.

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Fluorescent protein-based redox probes

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The Dithiol Glutaredoxins of African Trypanosomes Have Distinct Roles and Are Closely Linked to the Unique Trypanothione Metabolism

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Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity

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Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei

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A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage

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Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

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12 December 2020

Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase

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Fe/S protein biogenesis in trypanosomes - A review

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Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space.

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12 December 2020

The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione

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The cytosolic or the mitochondrial glutathione peroxidase-type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron-mediated mitochondrial damage and lysis

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12 December 2020

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12 December 2020

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12 December 2020

Identifiers

DOI

10.7554/ELIFE.53227

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32003744%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

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5 April 2020

PubMed publication ID

32003744

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