Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1 (Q88937969)

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29 March 2020

title

Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1 (English)

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29 March 2020

1

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author name string

Margaret O James

2

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29 March 2020

Marci G Smeltz

3

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29 March 2020

Stephan C Jahn

4

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29 March 2020

Taimour Langaee

5

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29 March 2020

Pippa Simpson

6

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29 March 2020

Peter W Stacpoole

7

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publication date

31 May 2018

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Drug Metabolism and Disposition

29 March 2020

published in

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volume

46

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issue

8

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29 March 2020

page(s)

1118-1128

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Affinity labeling of gamma-glutamyl transpeptidase and location of the gamma-glutamyl binding site on the light subunit

29 March 2020

cites work

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12 December 2020

A fluorometric method for determination of oxidized and reduced glutathione in tissues

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12 December 2020

Subcellular fractionation of human liver

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12 December 2020

Status of the mitochondrial pool of glutathione in the isolated hepatocyte

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12 December 2020

Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue

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12 December 2020

Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats

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12 December 2020

Clinical pharmacology and toxicology of dichloroacetate

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12 December 2020

Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.

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12 December 2020

Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids

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12 December 2020

Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at ser128.

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12 December 2020

Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis

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12 December 2020

Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate

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12 December 2020

Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity

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12 December 2020

Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone

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12 December 2020

Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues

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12 December 2020

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation

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12 December 2020

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search

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12 December 2020

Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70.

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12 December 2020

Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency

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12 December 2020

Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique

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12 December 2020

The effect of growth and function on the chemical composition of soft tissues

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12 December 2020

A statistical model for identifying proteins by tandem mass spectrometry

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12 December 2020

Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

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12 December 2020

Gene expression of gamma-glutamyltranspeptidase

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12 December 2020

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

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12 December 2020

Investigating MS2/MS3 matching statistics: a model for coupling consecutive stage mass spectrometry data for increased peptide identification confidence

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12 December 2020

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity

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12 December 2020

Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate

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12 December 2020

Comparison of metal and metal oxide media for phosphopeptide enrichment prior to mass spectrometric analyses

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12 December 2020

Dual targeting of mitochondrial proteins: mechanism, regulation and function

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12 December 2020

Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

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12 December 2020

The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither?

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12 December 2020

Subcellular phosphoproteomics

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12 December 2020

Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties ofGstz1−/−mice

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12 December 2020

Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease

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12 December 2020

Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate

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12 December 2020

Glutathione synthesis

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12 December 2020

Isolation of plasma membrane–associated membranes from rat liver

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12 December 2020

The protein import machinery of mitochondria-a regulatory hub in metabolism, stress, and disease

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12 December 2020

Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner

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12 December 2020

Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a).

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12 December 2020

Glutathione and mitochondria

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12 December 2020

Dual-targeted proteins tend to be more evolutionarily conserved.

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12 December 2020

Dichloroacetate and cancer: new home for an orphan drug?

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12 December 2020

Proteomics. Tissue-based map of the human proteome

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12 December 2020

The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.

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12 December 2020

Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.

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12 December 2020

Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny.

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12 December 2020

Pharmacogenetic considerations with dichloroacetate dosing

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12 December 2020

Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

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12 December 2020

Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency.

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12 December 2020

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

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12 December 2020

Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration

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12 December 2020

Identifiers

DOI

10.1124/DMD.118.081810

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29 March 2020

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29 March 2020

PubMed publication ID

29853471

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