Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme (Q81615619)

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10 January 2020

review article

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title

Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme (English)

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10 January 2020

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2

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10 January 2020

4

Tom Mikkelsen

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10 January 2020

author name string

David A Reardon

series ordinal

1

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10 January 2020

Roger Stupp

series ordinal

3

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10 January 2020

publication date

1 August 2008

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Expert Opinion on Investigational Drugs

10 January 2020

published in

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10 January 2020

volume

17

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10 January 2020

issue

8

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10 January 2020

page(s)

1225-1235

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Molecular signaling mechanisms of cell migration and invasion

10 January 2020

cites work

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12 December 2020

Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma

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12 December 2020

Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption

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Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist

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Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery.

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Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins

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Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo

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Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase.

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12 December 2020

alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin

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12 December 2020

Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts

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12 December 2020

Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin

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12 December 2020

Get a ligand, get a life: integrins, signaling and cell survival

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12 December 2020

Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins αvβ3 and αvβ5 in patients with advanced solid tumours

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12 December 2020

alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro.

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12 December 2020

RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells

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12 December 2020

Characterization of integrin receptors in normal and neoplastic human brain.

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12 December 2020

Requirement of vascular integrin alpha v beta 3 for angiogenesis

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12 December 2020

Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue.

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12 December 2020

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

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12 December 2020

Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves alphaV and beta1 integrins.

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12 December 2020

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases

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12 December 2020

Expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors

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12 December 2020

Kinetic analysis of integrin-dependent cell adhesion on vitronectin--the inhibitory potential of plasminogen activator inhibitor-1 and RGD peptides

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12 December 2020

The role of integrins in the malignant phenotype of gliomas

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12 December 2020

Astrocytoma adhesion to extracellular matrix: functional significance of integrin and focal adhesion kinase expression

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12 December 2020

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

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12 December 2020

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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12 December 2020

MGMT gene silencing and benefit from temozolomide in glioblastoma

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12 December 2020

Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy

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12 December 2020

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

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12 December 2020

Angiogenesis in gliomas: biology and molecular pathophysiology

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12 December 2020

Integrins: molecular targets in cancer therapy

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12 December 2020

Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models

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12 December 2020

Molecular mediators of alphavbeta3-induced endothelial cell survival

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12 December 2020

Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells

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12 December 2020

Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice

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12 December 2020

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma

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12 December 2020

Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma.

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12 December 2020

Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro

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12 December 2020

Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors

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12 December 2020

The biology of integrins

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12 December 2020

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12 December 2020

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme

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12 December 2020

Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761.

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12 December 2020

Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012.

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12 December 2020

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

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12 December 2020

10.1517/13543784.17.8.1225

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18616418%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18616418%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PubMed publication ID

18616418

1 reference