Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2 (Q80777899)

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scientific article published on 09 August 2007

Language	Label	Description	Also known as
English	Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2	scientific article published on 09 August 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2 (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

multiple drug resistance

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

S Shukla

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Z E Sauna

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

S V Ambudkar

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

publication date

9 August 2007

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

22

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

445-447

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17690695%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines

1 reference

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Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels

1 reference

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7 January 2021

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P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate

1 reference

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7 January 2021

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Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

1 reference

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The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

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High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter

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Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro

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Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.

1 reference

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Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

1 reference

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Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia

1 reference

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based on heuristic

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