Intratumoral injection of IL-12 plasmid DNA--results of a phase I/IB clinical trial (Q80448479)

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31 December 2019

title

Intratumoral injection of IL-12 plasmid DNA--results of a phase I/IB clinical trial (English)

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31 December 2019

main subject

phase I clinical trial

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Mahvi DM

1

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31 December 2019

Henry MB

2

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31 December 2019

Albertini MR

3

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31 December 2019

Weber S

4

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31 December 2019

Meredith K

5

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31 December 2019

Schalch H

6

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31 December 2019

Rakhmilevich A

7

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31 December 2019

Hank J

8

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31 December 2019

Sondel P

9

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publication date

8 June 2007

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31 December 2019

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31 December 2019

volume

14

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31 December 2019

issue

8

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31 December 2019

page(s)

717-723

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Cancer immunotherapy by direct in vivo transfer of immunomodulatory genes

31 December 2019

cites work

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Cytokine Gene Therapy of Cancer Using Gene Gun Technology: Superior Antitumor Activity of Interleukin-12

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Antitumor Efficacy of Adenocarcinoma Cells Engineered to Produce Interleukin 12 (IL-12) or Other Cytokines Compared With Exogenous IL-12

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Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma.

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Role of NK and T cells in IL-12-induced anti-tumor response against hepatic colon carcinoma

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Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

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Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism

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Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors

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Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

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Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo

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Inhibition of angiogenesis in vivo by interleukin 12.

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Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors

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Murine models of cancer cytokine gene therapy using interleukin-12.

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The toxicology of interleukin-12: a review

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Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

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7 January 2021

Neural toxicity of retroviruses

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7 January 2021

Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

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7 January 2021

Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors

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7 January 2021

Virus treatment questioned after gene therapy death

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7 January 2021

Interleukin-12 gene transfer results in CD8-dependent regression of murine CT26 liver tumors

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7 January 2021

Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA.

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7 January 2021

Introduction of murine Il-4 gene into B16(F10) melanoma tumors by direct gene transfer with DNA-liposome complexes

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7 January 2021

Tissue distribution of the cytofectin component of a plasmid-DNA/cationic lipid complex following intravenous administration in mice

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7 January 2021

A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo

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7 January 2021

Intratracheal administration of interleukin 12 plasmid-cationic lipid complexes inhibits murine lung metastases

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7 January 2021

A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon alpha

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7 January 2021

Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity

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7 January 2021

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7 January 2021

Particle-mediated gene transfer of granulocyte-macrophage colony-stimulating factor cDNA to tumor cells: implications for a clinically relevant tumor vaccine

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7 January 2021

Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA.

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7 January 2021

Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine interleukin 12

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7 January 2021

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7 January 2021

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7 January 2021

IL-12 + GM-CSF microsphere therapy induces eradication of advanced spontaneous tumors in her-2/neu transgenic mice but fails to achieve long-term cure due to the inability to maintain effector T-cell activity

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7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7701064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17557109%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference