The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis (Q73675913)

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5 November 2019

title

The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis (English)

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5 November 2019

author name string

Kwon Y

series ordinal

1

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5 November 2019

Shin BS

series ordinal

2

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5 November 2019

Chung IK

series ordinal

3

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5 November 2019

language of work or name

English

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publication date

1 June 2000

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Journal of Biological Chemistry

5 November 2019

published in

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5 November 2019

volume

275

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5 November 2019

issue

24

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5 November 2019

page(s)

18503-18510

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DNA topoisomerases: essential enzymes and lethal targets

5 November 2019

cites work

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Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

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Structure and function of type II DNA topoisomerases

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Structure and mechanism of DNA topoisomerase II

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DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism

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DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication

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DNA topoisomerase II is required at the time of mitosis in yeast

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Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro

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Supercoiling of the DNA template during transcription

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Topoisomerase II is a structural component of mitotic chromosome scaffolds.

21 January 2018

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Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster.

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When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

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Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

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Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors

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Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells

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Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors

21 January 2018

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Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes

21 January 2018

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Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24

21 January 2018

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Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

21 January 2018

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p53 regulates the minimal promoter of the human topoisomerase IIalpha gene

21 January 2018

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Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor

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p53, the cellular gatekeeper for growth and division

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p53: puzzle and paradigm

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Suppression of human colorectal carcinoma cell growth by wild-type p53

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p53 function and dysfunction

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Wild-type p53 activates transcription in vitro

21 January 2018

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Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element

21 January 2018

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Wild-type p53 can down-modulate the activity of various promoters

21 January 2018

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Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product

21 January 2018

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Negative regulation of Rb expression by the p53 gene product

21 January 2018

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

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WAF1, a potential mediator of p53 tumor suppression

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

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Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene

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Reduced activity of topoisomerase II in an Adriamycin-resistant human stomach-adenocarcinoma cell line

21 January 2018

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21 January 2018

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21 January 2018

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Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

21 January 2018

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Binding of wild-type p53 by topoisomerase II and overexpression of topoisomerase II in human hepatocellular carcinoma

21 January 2018

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Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation

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Modulation of DNA Topoisomerase I Activity byp53

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Casein kinase II stabilizes the activity of human topoisomerase IIalpha in a phosphorylation-independent manner

21 January 2018

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21 January 2018

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Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53

21 January 2018

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The cell cycle-coupled expression of topoisomerase IIalpha during S phase is regulated by mRNA stability and is disrupted by heat shock or ionizing radiation

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Identifiers

DOI

10.1074/JBC.M002081200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10764786%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference