Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis (Q73561089)

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5 November 2019

title

Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis (English)

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5 November 2019

1

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5 November 2019

author name string

M C Jong

2

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5 November 2019

L C van Vark

3

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5 November 2019

H van der Boom

4

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5 November 2019

W L Hendriks

5

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5 November 2019

T J van Berkel

6

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5 November 2019

E A Biessen

7

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5 November 2019

L M Havekes

8

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5 November 2019

language of work or name

English

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publication date

1 March 2000

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Journal of Biological Chemistry

5 November 2019

published in

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5 November 2019

volume

275

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issue

12

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5 November 2019

page(s)

8564-8571

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

5 November 2019

cites work

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Selective liver targeting of antivirals by recombinant chylomicrons--a new therapeutic approach to hepatitis B

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Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway

21 January 2018

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Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist

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The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein

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Heparan Sulfate Proteoglycan-Mediated Uptake of Apolipoprotein E−Triglyceride-Rich Lipoprotein Particles: A Major Pathway at Physiological Particle Concentrations

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Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4.

21 January 2018

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Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both

21 January 2018

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Receptor-mediated endocytosis: insights from the lipoprotein receptor system

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Rate and equilibrium constants for binding of apo-E HDL c (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDL c

21 January 2018

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Human Recombinant Apolipoprotein E-Enriched Liposomes Can Mimic Low-Density Lipoproteins as Carriers for the Site-Specific Delivery of Antitumor Agents

21 January 2018

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Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages

21 January 2018

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The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages

21 January 2018

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Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages

21 January 2018

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Enhanced metabolism of normolipidemic human plasma very low density lipoprotein in cultured cells by exogenous apolipoprotein E-3

21 January 2018

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Effects of apoprotein E on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake

21 January 2018

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Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes

21 January 2018

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Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia

21 January 2018

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Recycling of apolipoprotein E in mouse liver

21 January 2018

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Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo

21 January 2018

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Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice

21 January 2018

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Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E.

21 January 2018

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Separation of plasma lipoproteins by density-gradient ultracentrifugation

21 January 2018

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Plasma factors affecting the in vitro conversion of high-density lipoproteins labeled with a non-transferable marker

21 January 2018

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Efficient Trace-labelling of Proteins with Iodine

21 January 2018

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Metabolism of protein-free lipid emulsion models of chylomicrons in rats

21 January 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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Low-density lipoproteins are degraded in HepG2 cells with low efficiency

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19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

21 January 2018

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Cholesterol derivative of a new triantennary cluster galactoside directs low- and high-density lipoproteins to the parenchymal liver cell

21 January 2018

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Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG

21 January 2018

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Binding of beta-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas ApoE only modulates binding affinity

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.275.12.8564

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10722695%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference