Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53 (Q73446293)

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scientific article published on 01 May 2003

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English	Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53	scientific article published on 01 May 2003

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4 November 2019

Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53 (English)

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Europe PubMed Central

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4 November 2019

Robert G. Bristow

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4 November 2019

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James Peacock

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4 November 2019

Anne Jang

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4 November 2019

John Kim

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4 November 2019

Richard P Hill

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4 November 2019

Samuel Benchimol

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4 November 2019

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1 May 2003

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4 November 2019

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4 November 2019

22

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4 November 2019

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4 November 2019

2960-2966

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4 November 2019

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

1 reference

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Gain of function mutations in p53.

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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Genome maintenance mechanisms for preventing cancer

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Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage.

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Mutant p53 protein expression interferes with p53-independent apoptotic pathways

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Tumour p53 mutations exhibit promoter selective dominance over wild type p53.

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The p53-mediated G1 checkpoint is retained in tumorigenic rat embryo fibroblast clones transformed by the human papillomavirus type 16 E7 gene and EJ-ras.

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Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil

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