Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms (Q73371204)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12738056%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

review article

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MDMA

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title

Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12738056%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

1 reference

Johnalyn Lyles

1

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3 November 2019

Jean Lud Cadet

2

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3 November 2019

language of work or name

English

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National Center for Biotechnology Information

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31 December 2023

publication date

1 May 2003

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full work available at URL

3 November 2019

https://api.elsevier.com/content/article/PII:S0165017303001735?httpAccept=text/xml

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https://api.elsevier.com/content/article/PII:S0165017303001735?httpAccept=text/plain

31 December 2023

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Brain research. Brain research reviews

31 December 2023

published in

42

2

155–68

May 2003

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12738056

31 December 2023

volume

42

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3 November 2019

issue

2

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3 November 2019

page(s)

155-168

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Developmental pattern of reactive oxygen species generation and antioxidative defense machinery in rat cerebral microvessels.

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7 January 2021

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Effect of 3,4-Methylenedioxymethamphetamine on 3,4-Dihydroxyphenylalanine Accumulation in the Striatum and Nucleus Accumbens

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7 January 2021

Methylenedioxymethamphetamine-induced inhibition of neuronal firing in the nucleus accumbens is mediated by both serotonin and dopamine

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7 January 2021

Ecstasy--long-term effects on the human central nervous system revealed by positron emission tomography

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Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity.

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7 January 2021

Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat.

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7 January 2021

The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').

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Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA)

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Cognitive performance in recreational users of MDMA of 'ecstasy': evidence for memory deficits

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7 January 2021

Psychobiological problems in heavy 'ecstasy' (MDMA) polydrug users

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7 January 2021

Neuroendocrine and mood responses to intravenous L-tryptophan in 3,4-methylenedioxymethamphetamine (MDMA) users. Preliminary observations

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7 January 2021

Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons

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7 January 2021

The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in rat and human brain

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7 January 2021

Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"): preliminary findings

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https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Aminergic Metabolites in Cerebrospinal Fluid of Humans Previously Exposed to MDMA: Preliminary Observations

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Assessing long-term effects of MDMA (Ecstasy).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy').

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

A new pharmophoric model for 5-HT reuptake-inhibitors: differentiation of amphetamine analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Neurotoxicity of MDMA: neurochemical effects

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

The abused drug MDMA (Ecstasy) induces programmed death of human serotonergic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

CSF studies in violent offenders. I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Recreational MDMA use in Sydney: a profile of 'Ecstacy' users and their experiences with the drug

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Behavioral and neurochemical effects of prenatal methylenedioxymethamphetamine (MDMA) exposure in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Nitric oxide-dependent damage to neuronal mitochondria involves the NMDA receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Cognitive performance and serotonergic function in users of ecstasy.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Psychological and cardiovascular effects and short-term sequelae of MDMA ("ecstasy") in MDMA-naïve healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Working memory deficits in current and previous users of MDMA ('ecstasy').

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular levels of dopamine and serotonin in the nucleus accumbens in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

The effects of methylenedioxymethamphetamine (MDMA, "Ecstasy") on monoaminergic neurotransmission in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Release of serotonin induced by 3,4-methylenedioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further evidence for calcium-independent mechanisms of release

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Adverse effects of stimulant drugs in a community sample of drug users.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Fetal exposure to (+/-)-methylenedioxymethamphetamine in utero enhances the development and metabolism of serotonergic neurons in three-dimensional reaggregate tissue culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-0173%2803%2900173-5

7 January 2021

Rat lung antioxidant enzymes: differences in perinatal gene expression and regulation

27

1 reference

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Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat

31 December 2023

90

1 reference

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Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors

31 December 2023

113

1 reference

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Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine

31 December 2023

115

1 reference

https://api.crossref.org/works/10.1016/S0165-0173(03)00173-5

Ecstasy: towards an understanding of the biochemical basis of the actions of MDMA

31 December 2023

130

1 reference

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Studies of MDMA-induced neurotoxicity in nonhuman primates: a basis for evaluating long-term effects in humans

31 December 2023

135

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5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa

31 December 2023

157

1 reference

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Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction

31 December 2023

161

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An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine

31 December 2023

171

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Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine

31 December 2023

179

1 reference

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Nitric oxide and the neurotoxic effects of methamphetamine and 3,4-methylenedioxymethamphetamine

31 December 2023

182

1 reference

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31 December 2023

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12738056%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference