Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition (Q63246569)

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5 May 2020

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5 May 2020

author name string

Nan Zhou

1

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5 May 2020

Kaili Liu

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5 May 2020

Yue Sun

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5 May 2020

Ying Cao

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5 May 2020

language of work or name

English

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publication date

February 2019

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published in

Protein & Cell

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volume

10

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issue

2

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5 May 2020

page(s)

87-103

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Creative Commons Attribution 4.0 International

5 May 2020

copyright license

start time

27 November 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

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12 December 2020

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

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Regulation of the PU.1 gene by distal elements

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The ETS-domain transcription factor family

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Potential autoregulation of transcription factor PU.1 by an upstream regulatory element

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Microglia recognize double-stranded RNA via TLR3.

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Debris clearance by microglia: an essential link between degeneration and regeneration.

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Regulation and function of NF-kappaB transcription factors in the immune system

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Regulation of innate immune responses in the brain

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Hypothalamic inflammation and energy homeostasis: resolving the paradox

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Microglia in neurodegenerative disease

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The myeloid cells of the central nervous system parenchyma

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Physiology of microglia

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Genomic and biochemical insights into the specificity of ETS transcription factors

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Innate immunity in the central nervous system

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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

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The complement system: an unexpected role in synaptic pruning during development and disease

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IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype

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Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia

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IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS.

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Inflammatory monocytes and the pathogenesis of viral encephalitis

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Microglia: scapegoat, saboteur, or something else?

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Microglia: new roles for the synaptic stripper.

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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

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Factors regulating microglia activation

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A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

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Phagocytosis of microglia in the central nervous system diseases

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Microglia development and function

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The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation

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Microglial priming in neurodegenerative disease

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Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

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The complex role of neuroinflammation in glaucoma

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iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging.

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Pathological axonal death through a MAPK cascade that triggers a local energy deficit

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Hypothalamic inflammation in the control of metabolic function

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Roles of microglia in brain development, tissue maintenance and repair.

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Hypothalamic innate immune reaction in obesity

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Microglia Function in Central Nervous System Development and Plasticity

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Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

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Microglia Function in the Central Nervous System During Health and Neurodegeneration

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Ontogeny and homeostasis of CNS myeloid cells

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Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation

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Elucidating the Role of TREM2 in Alzheimer's Disease

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Myeloid Cells in the Central Nervous System

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Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia

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Microglia and macrophages in brain homeostasis and disease

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Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

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10.1007/S13238-018-0599-3

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30484118%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30484118%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

PubMed publication ID

30484118

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