Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway (Q58114487)

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scientific article published on 26 October 2018

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English	Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway	scientific article published on 26 October 2018

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scholarly article

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26 August 2020

19 January 2021

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway (English)

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1 May 2020

breast neoplasm

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26 August 2020

19 January 2021

signal transduction

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26 August 2020

neoplasm invasiveness

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19 January 2021

4

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1 May 2020

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Young Shin Ko

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Trojan Rugira

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Hana Jin

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26 October 2018

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19 January 2021

International Journal of Molecular Sciences

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19

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Creative Commons Attribution

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0 references

Comparison of the effect of steroid lactones on the transport-ATPase and ion transport of erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

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Structure and function of the Na,K pump: ten years of molecular biology.

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12 December 2020

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Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function.

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12 December 2020

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Reduced expression of beta-subunit of Na,K-ATPase in human clear-cell renal cell carcinoma

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Regulation of expression of Na+,K+-ATPase in androgen-dependent and androgen-independent prostate cancer

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12 December 2020

based on heuristic

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Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells

1 reference

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12 December 2020

based on heuristic

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Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase

1 reference

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12 December 2020

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Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin

1 reference

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12 December 2020

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Signal Transduction and the Control of Gene Expression

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12 December 2020

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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

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12 December 2020

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Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process

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12 December 2020

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Stats: transcriptional control and biological impact

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12 December 2020

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Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells

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12 December 2020

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Analysis of the Na,K-ATPase α- and β-subunit expression profiles of bladder cancer using tissue microarrays

1 reference

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12 December 2020

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STAT proteins: From normal control of cellular events to tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

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Oleandrin suppresses activation of nuclear transcription factor-κB and activator protein-1 and potentiates apoptosis induced by ceramide

1 reference

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12 December 2020

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Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5.

1 reference

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12 December 2020

based on heuristic

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The STATs of cancer--new molecular targets come of age

1 reference

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12 December 2020

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Up-regulation of Na(+),K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer

1 reference

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12 December 2020

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Antiapoptotic effect of ouabain on human umbilical vein endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

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Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

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Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

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Oleandrin-mediated oxidative stress in human melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

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Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

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Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells

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12 December 2020

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Cardiac glycosides as novel cancer therapeutic agents

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https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

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Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

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Novel therapeutic applications of cardiac glycosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

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Reciprocal effects of STAT5 and STAT3 in breast cancer

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Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma

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12 December 2020

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Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets

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STATs in cancer inflammation and immunity: a leading role for STAT3

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Oral administration of penta-O-galloyl- -D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition

1 reference

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SHP-1 in cell-cycle regulation

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Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.

1 reference

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12 December 2020

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The cancer stem cell: premises, promises and challenges

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12 December 2020

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The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

1 reference

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12 December 2020

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Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway

1 reference

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12 December 2020

based on heuristic

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The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the interleukin-6/Jak/stat pathway in human malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiotonic steroids-mediated Na+/K+-ATPase targeting could circumvent various chemoresistance pathways

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trial watch: Cardiac glycosides and cancer therapy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Digoxin downregulates NDRG1 and VEGF through the inhibition of HIF-1α under hypoxic conditions in human lung adenocarcinoma A549 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and pharmacological blockade of sodium-potassium ATPase: a novel pathway to neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3 Target Genes Relevant to Human Cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluating the cancer therapeutic potential of cardiac glycosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of STAT3 signaling in mediating tumor resistance to cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Notch inhibitor cowanin accelerates nicastrin degradation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a sodium pump Na/K ATPase α1-targeted peptide for PET imaging of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioresistant breast cancer cells exhibit increased resistance to chemotherapy and enhanced invasive properties due to cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30373171

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS19113350

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1 May 2020

PMC publication ID

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Europe PubMed Central

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1 May 2020

PubMed publication ID

1 reference

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1 May 2020

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