Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease? (Q57418361)

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31 March 2020

title

Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease? (English)

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31 March 2020

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1

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31 March 2020

Bruno A Benitez

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29889572%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Carlos Cruchaga

series ordinal

4

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31 March 2020

author name string

Zeran Li

series ordinal

2

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31 March 2020

language of work or name

English

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publication date

20 June 2018

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Expert Opinion on Therapeutic Targets

31 March 2020

published in

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31 March 2020

volume

22

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31 March 2020

issue

7

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31 March 2020

page(s)

587-598

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

31 March 2020

cites work

1 reference

12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

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CNS manifestations of Nasu-Hakola disease: a frontal dementia with bone cysts

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

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Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

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Impaired differentiation of osteoclasts in TREM-2-deficient individuals

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12 December 2020

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

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12 December 2020

Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes

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12 December 2020

TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

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12 December 2020

Role of Genes and Environments for Explaining Alzheimer Disease

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12 December 2020

Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.

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12 December 2020

Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia.

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12 December 2020

Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

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12 December 2020

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

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12 December 2020

Cutting Edge: TREM-2 Attenuates Macrophage Activation

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12 December 2020

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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12 December 2020

Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults

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12 December 2020

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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12 December 2020

Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis

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12 December 2020

TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis

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12 December 2020

Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response

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12 December 2020

Mutations in TREM2 lead to pure early-onset dementia without bone cysts.

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12 December 2020

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

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12 December 2020

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

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12 December 2020

YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease

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12 December 2020

Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease

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12 December 2020

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

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12 December 2020

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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12 December 2020

TREM2 Variants in Alzheimer's Disease

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12 December 2020

Microglia: actively surveying and shaping neuronal circuit structure and function.

1 reference

12 December 2020

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

1 reference

12 December 2020

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

1 reference

12 December 2020

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

1 reference

12 December 2020

Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

1 reference

12 December 2020

Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients

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12 December 2020

Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease

1 reference

12 December 2020

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

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12 December 2020

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

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12 December 2020

Heterozygous TREM2 mutations in frontotemporal dementia

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12 December 2020

Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases

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12 December 2020

TREM2 and the neuroimmunology of Alzheimer's disease

1 reference

12 December 2020

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

1 reference

12 December 2020

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease

1 reference

12 December 2020

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease

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12 December 2020

Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid

1 reference

12 December 2020

Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase

1 reference

12 December 2020

Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease

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12 December 2020

Human-induced pluripotent stem cells: potential for neurodegenerative diseases

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12 December 2020

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

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12 December 2020

Coding variants in TREM2 increase risk for Alzheimer's disease

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12 December 2020

Amyloid-directed monoclonal antibodies for the treatment of Alzheimer's disease: the point of no return?

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12 December 2020

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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12 December 2020

Cerebrospinal fluid level of YKL-40 protein in preclinical and prodromal Alzheimer's disease

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12 December 2020

Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Never-resting microglia: physiological roles in the healthy brain and pathological implications

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12 December 2020

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

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12 December 2020

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus

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12 December 2020

TREM2 regulates microglial cell activation in response to demyelination in vivo

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12 December 2020

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.

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12 December 2020

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

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12 December 2020

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

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12 December 2020

TREM2 is associated with increased risk for Alzheimer's disease in African Americans

1 reference

12 December 2020

Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age.

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12 December 2020

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

1 reference

12 December 2020

Microglia: Dynamic Mediators of Synapse Development and Plasticity.

1 reference

12 December 2020

Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease

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12 December 2020

Accelerating stem cell trials for Alzheimer's disease

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12 December 2020

Current status of treating neurodegenerative disease with induced pluripotent stem cells

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12 December 2020

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease

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12 December 2020

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

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12 December 2020

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

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12 December 2020

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

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12 December 2020

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

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12 December 2020

Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury

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12 December 2020

Assessment of the genetic variance of late-onset Alzheimer's disease

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12 December 2020

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

1 reference

12 December 2020

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

1 reference

12 December 2020

Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials

1 reference

12 December 2020

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease

1 reference

12 December 2020

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

1 reference

12 December 2020

TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects

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12 December 2020

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.

1 reference

12 December 2020

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease

1 reference

12 December 2020

Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model

1 reference

12 December 2020

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

1 reference

12 December 2020

Vps35-dependent recycling of Trem2 regulates microglial function

1 reference

12 December 2020

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains

1 reference

12 December 2020

TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation

1 reference

12 December 2020

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

1 reference

12 December 2020

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

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12 December 2020

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

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12 December 2020

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

1 reference

12 December 2020

CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

1 reference

12 December 2020

Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease

1 reference

12 December 2020

TREM2-Ligand Interactions in Health and Disease

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12 December 2020

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

1 reference

12 December 2020

A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells

1 reference

12 December 2020

Stop Alzheimer's before it starts

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12 December 2020

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

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12 December 2020

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

1 reference

12 December 2020

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

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12 December 2020

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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12 December 2020

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

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12 December 2020

Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms

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12 December 2020

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.

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12 December 2020

10.1080/14728222.2018.1486823

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29889572%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

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31 March 2020

PubMed publication ID

29889572

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