Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo (Q57274183)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17142251%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo (English)

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22 December 2019

6

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22 December 2019

8

Cynthia T McMurray

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22 December 2019

1

Eugenia Trushina

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22 December 2019

author name string

Raman Deep Singh

2

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22 December 2019

Sheng Cao

4

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22 December 2019

Roy B Dyer

3

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22 December 2019

Vijay H Shah

5

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22 December 2019

Richard E Pagano

7

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22 December 2019

publication date

1 December 2006

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22 December 2019

published in

Human Molecular Genetics

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22 December 2019

volume

15

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22 December 2019

issue

24

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22 December 2019

page(s)

3578-3591

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The hunt for huntingtin function: interaction partners tell many different stories

22 December 2019

cites work

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HAP1 and intracellular trafficking

21 January 2018

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A human HAP1 homologue. Cloning, expression, and interaction with huntingtin

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Fast transport and retrograde movement of huntingtin and HAP 1 in axons

21 January 2018

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Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

21 January 2018

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Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

21 January 2018

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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

21 January 2018

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

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Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

21 January 2018

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

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Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

21 January 2018

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Endoplasmic reticulum stress response and neurodegeneration

21 January 2018

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Accomplices to neuronal death

21 January 2018

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Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways

21 January 2018

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Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.

21 January 2018

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It's HIP to be a hub: new trends for old-fashioned proteins

21 January 2018

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An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles

21 January 2018

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HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

21 January 2018

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HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

21 January 2018

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The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

21 January 2018

1 reference

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Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain

21 January 2018

1 reference

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Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo

21 January 2018

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End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae.

21 January 2018

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Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

21 January 2018

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Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking

21 January 2018

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Mouse Huntington's disease gene homolog (Hdh).

21 January 2018

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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

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Selective caveolin-1-dependent endocytosis of glycosphingolipids

21 January 2018

1 reference

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Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albuminin Vivo

21 January 2018

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GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway.

21 January 2018

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Caveolin, a protein component of caveolae membrane coats

21 January 2018

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Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol

21 January 2018

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Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules

21 January 2018

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Glutamate regulates caveolin expression in rat hippocampal neurons

21 January 2018

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Rings of membrane sterols surround the openings of vesicles and fenestrae, in capillary endothelium

21 January 2018

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Caveolae and intracellular trafficking of cholesterol

21 January 2018

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Cholesterol deprivation affects the fluorescence properties of a ceramide analog at the Golgi apparatus of living cells

21 January 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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Mutant protein in Huntington disease is resistant to proteolysis in affected brain

21 January 2018

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The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function

21 January 2018

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Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

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Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin

21 January 2018

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Huntingtin associates with acidic phospholipids at the plasma membrane

21 January 2018

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CNS synaptogenesis promoted by glia-derived cholesterol

21 January 2018

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Cholesterol homeostasis failure as a unifying cause of synaptic degeneration

21 January 2018

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Cholesterol storage and tau pathology in Niemann–Pick type C disease in the brain

21 January 2018

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Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases

21 January 2018

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Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties.

21 January 2018

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Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

21 January 2018

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Trafficking of prion proteins through a caveolae-mediated endosomal pathway

21 January 2018

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Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

21 January 2018

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Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

21 January 2018

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Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

21 January 2018

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Internalization and sorting of a fluorescent analogue of glucosylceramide to the Golgi apparatus of human skin fibroblasts: utilization of endocytic and nonendocytic transport mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL434

Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL434

21 January 2018

Identifiers

DOI

10.1093/HMG/DDL434

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17142251%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

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