Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes (Q56672867)

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9 November 2019

title

Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes (English)

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6 December 2024

author name string

S. Werner

1

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S. Kunz

2

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T. Beckurts

3

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C. D. Heidecke

4

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T. Wolff

5

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L. R. Schwarz

6

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language of work or name

English

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publication date

1 December 1997

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9 November 2019

12 December 1997

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9465929

full work available at URL

6 December 2024

https://api.elsevier.com/content/article/PII:S1383571897001678?httpAccept=text/xml

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10.1016/S1383-5718(97)00167-8

DOI

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https://api.elsevier.com/content/article/PII:S1383571897001678?httpAccept=text/plain

6 December 2024

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10.1016/S1383-5718(97)00167-8

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6 December 2024

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volume

395

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9 November 2019

issue

2-3

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9 November 2019

page(s)

179-187

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Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures.

9 November 2019

cites work

1 reference

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7 January 2021

Cyproterone acetate is an integral part of hepatic DNA adducts induced by this steroidal drug.

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7 January 2021

Accumulation and persistence of DNA adducts of the synthetic steroid cyproterone acetate in rat liver.

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7 January 2021

DNA-damaging activity of the cyproterone acetate analogues chlormadinone acetate and megestrol acetate in rat liver

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7 January 2021

Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in gamma-glutamyltranspeptidase-positive cells

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7 January 2021

DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate

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7 January 2021

In vitro mutagenicity studies on cyproterone acetate using female rat hepatocytes for metabolic activation and as indicator cells

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7 January 2021

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7 January 2021

Formation of DNA-adducts by selected sex steroids in rat liver

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7 January 2021

Initiation of enzyme-altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay.

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7 January 2021

Induction of micronuclei and initiation of enzyme-altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate, or megestrol acetate.

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7 January 2021

Comparative study of DNA repair induced by cyproterone acetate, chlormadinone acetate and megestrol acetate in primary cultures of human and rat hepatocytes

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7 January 2021

Isolation and culture of adult hepatocytes from liver biopsies

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7 January 2021

EDTA alkaline elution characteristics and measurement of DNA damage in unlabeled DNA using Hoechst 33258 fluorescence

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7 January 2021

Formation and removal of DNA adducts in rat liver treated with N-hydroxy derivatives of 2-acetylaminofluorene, 4-acetylaminobiphenyl, and 2-acetylaminophenanthrene

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7 January 2021

Identification of 3α-hydroxy-cyproterone acetate as a metabolite of cyproterone acetate in the bile of female rats and the potential of this and other already known or putative metabolites to form DNA adducts in vitro

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7 January 2021

Use of rat and human liver slices for the detection of steroid hormone-induced DNA-adducts in vitro by means of the (32)P-postlabeling technique

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7 January 2021

Molecular cloning and functions of rat liver hydroxysteroid sulfotransferases catalysing covalent binding of carcinogenic polycyclic arylmethanols to DNA.

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7 January 2021

Studies on rat hepatic hydroxysteroid sulfotransferase--immunochemistry, development and pI variants

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7 January 2021

Human liver dehydroepiandrosterone sulfotransferase: nature and extent of individual variation

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7 January 2021

Metabolism of megestrol acetate and related progesterone analogues by liver preparations in vitro

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7 January 2021

Pharmacokinetics of cyproterone acetate and ethinylestradiol in 15 women who received a combination oral contraceptive during three treatment cycles

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7 January 2021

Non-mutagenicity of some sex hormones in the ames salmonella/microsome mutagenicity test

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7 January 2021

Studies for a genotoxic potential of some endogenous and exogenous sex steroids. I. Communication: examination for the induction of gene mutations using the Ames Salmonella/microsome test and the HGPRT test in V79 cells

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7 January 2021

Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells

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7 January 2021

Stable heterologous expression of hydroxysteroid sulphotransferase in Chinese hamster V79 cells and their use for toxicological investigations

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7 January 2021

10.1016/S1383-5718(97)00167-8

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9 November 2019

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