fibroblast growth factor receptor 2 (Q5446456)

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mammalian protein found in Homo sapiens
  • K-sam
  • fibroblast growth factor receptor 2
  • protein tyrosine kinase, receptor like 14
  • KGFR
  • bacteria-expressed kinase
  • keratinocyte growth factor receptor
  • FGFR2
  • BEK fibroblast growth factor receptor
edit
Language Label Description Also known as
English
fibroblast growth factor receptor 2
mammalian protein found in Homo sapiens
  • K-sam
  • fibroblast growth factor receptor 2
  • protein tyrosine kinase, receptor like 14
  • KGFR
  • bacteria-expressed kinase
  • keratinocyte growth factor receptor
  • FGFR2
  • BEK fibroblast growth factor receptor

Statements

part of
molecular function
fibroblast growth factor-activated receptor activity
determination method or standard
NAS
IDA
IGI
IEA
8 references
retrieved
7 November 2018
stated in
A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
NAS
retrieved
7 November 2018
stated in
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
NAS
retrieved
7 November 2018
stated in
Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
NAS
retrieved
7 November 2018
stated in
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
IGI
retrieved
7 November 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
IEA
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
IEA
retrieved
7 November 2018
stated in
Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
IDA
retrieved
7 November 2018
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802
determination method or standard
IDA
protein binding
determination method or standard
IPI
9 references
retrieved
8 April 2019
stated in
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural interactions of fibroblast growth factor receptor with its ligands
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of basal FGF receptor signaling by dimeric Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
fibroblast growth factor-activated receptor activity
determination method or standard
IBA
IDA
IEA
IGI
NAS
9 references
retrieved
8 April 2019
stated in
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
NAS
retrieved
8 April 2019
stated in
Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
NAS
retrieved
8 April 2019
stated in
A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
NAS
retrieved
8 April 2019
stated in
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IEA
retrieved
8 April 2019
stated in
Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IDA
retrieved
8 April 2019
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IBA
cell component
biological process
fibroblast growth factor receptor signaling pathway
determination method or standard
IDA
IGI
TAS
IEA
IPI
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
TAS
retrieved
8 April 2019
stated in
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IPI
retrieved
8 April 2019
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IEA
retrieved
8 April 2019
stated in
Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IDA
retrieved
8 April 2019
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
UniProt
UniProt protein ID
P21802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802
determination method or standard
IDA
Gene Atlas image
PBB GE FGFR2 208228 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051497
subject named as
Receptor, Fibroblast Growth Factor, Type 2
0 references
RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
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