Ferritin light chain (Q5445389)

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mammalian protein found in Homo sapiens

FTL
epididymis secretory sperm binding protein
ferritin light chain
ferritin light polypeptide-like 3
ferritin, light polypeptide
ferritin L-chain
ferritin L subunit

Language	Label	Description	Also known as
English	Ferritin light chain	mammalian protein found in Homo sapiens	FTL epididymis secretory sperm binding protein ferritin light chain ferritin light polypeptide-like 3 ferritin, light polypeptide ferritin L-chain ferritin L subunit

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02792

Ferritin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02792

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02792

Ferritin-like diiron domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ferritin/DPS protein domain family

1 reference

based on heuristic

inferred from protein domain or family

Ferritin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

iron ion binding

determination method or standard

3 references

26 September 2017

Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

protein binding

determination method or standard

9 references

8 April 2019

Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

A human protein-protein interaction network: a resource for annotating the proteome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Development and application of a DNA microarray-based yeast two-hybrid system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

ferric iron binding

determination method or standard

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

identical protein binding

determination method or standard

5 references

26 September 2017

A human protein-protein interaction network: a resource for annotating the proteome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

Structure of human ferritin L chain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

ferroxidase activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

iron ion binding

determination method or standard

4 references

8 April 2019

Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

ferrous iron binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

identical protein binding

determination method or standard

6 references

8 April 2019

A human protein-protein interaction network: a resource for annotating the proteome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Structure of human ferritin L chain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

extracellular exosome

determination method or standard

3 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

intracellular ferritin complex

determination method or standard

3 references

8 April 2019

Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation")

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

determination method or standard

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02792&geneProductId=UniProtKB:P02792

determination method or standard

extracellular region

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

azurophil granule lumen

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

determination method or standard

1 reference

8 April 2019

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

intracellular ferritin complex

determination method or standard

4 references

1 January 2018

Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation")

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

1 January 2018

Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

1 January 2018

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

determination method or standard

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

determination method or standard

biological process

iron ion homeostasis

determination method or standard

1 reference

8 April 2019

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

iron ion transport

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

cellular iron ion homeostasis

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation")

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

intracellular sequestering of iron ion

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02792

determination method or standard

Gene Atlas image

PBB GE FTL 212788 x at fs.png
732 × 530; 12 KB

0 references

ferritin/DPS protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02792

ferritin-like diiron domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02792

ferritin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02792

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000366525

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366525

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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