An essential role for Akt1 in dendritic cell function and tumor immunotherapy. (Q53583550)

15 May 2018

title

An essential role for Akt1 in dendritic cell function and tumor immunotherapy. (English)

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15 May 2018

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Dongsu Park

1

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15 May 2018

Natalia Lapteva

2

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15 May 2018

Mamatha Seethammagari

3

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15 May 2018

Kevin M Slawin

4

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15 May 2018

David M Spencer

5

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15 May 2018

publication date

3 December 2006

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15 May 2018

published in

Nature Biotechnology

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15 May 2018

volume

24

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15 May 2018

issue

12

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15 May 2018

page(s)

1581-1590

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15 May 2018

Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3'-OH kinase pathway.

cites work

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The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell m

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Prostaglandin E2 promotes the survival of bone marrow-derived dendritic cells

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Ceramide mediates tumor-induced dendritic cell apoptosis

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Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages

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The use of dendritic cells in cancer immunotherapy

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The first 1000 dendritic cell vaccinees

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CD8+ T Cell-Dependent Elimination of Dendritic Cells In Vivo Limits the Induction of Antitumor Immunity

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Immune tolerance after delivery of dying cells to dendritic cells in situ

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TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo

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Bcl-2 controls dendritic cell longevity in vivo

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Dendritic cell development and survival require distinct NF-kappaB subunits

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Membrane-anchored CD40 Is Processed by the Tumor Necrosis Factor-α-converting Enzyme

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Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo.

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Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

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SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

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IRAK-M is a negative regulator of Toll-like receptor signaling

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7 January 2021

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

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Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity

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7 January 2021

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

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7 January 2021

A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells

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7 January 2021

Advances in protein kinase B signalling: AKTion on multiple fronts

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Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation

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7 January 2021

The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells

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7 January 2021

Ranking the role of RANK ligand in apoptosis

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7 January 2021

Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide

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7 January 2021

Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression

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7 January 2021

Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation

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7 January 2021

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

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7 January 2021

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

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Natural adjuvants: endogenous activators of dendritic cells

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7 January 2021

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

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7 January 2021

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

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7 January 2021

Lipid-dependent recruitment of neuronal Src to lipid rafts in the brain

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7 January 2021

A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis

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7 January 2021

Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

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Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy

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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

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Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions

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The role of Asp-462 in regulating Akt activity

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7 January 2021

Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells

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7 January 2021

PI3K-mediated negative feedback regulation of IL-12 production in DCs

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7 January 2021

Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

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Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice

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Innate immune sensing and its roots: the story of endotoxin

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Requirement for CD154 in the progression of atherosclerosis.

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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

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7 January 2021

Versatile prostate cancer treatment with inducible caspase and interleukin-12.

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7 January 2021

Identifiers

DOI

10.1038/NBT1262

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15 May 2018

Dimensions Publication ID

1030139308

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15 May 2018