IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma. (Q52723729)

http://europepmc.org/abstract/PMC/6485619

2 July 2019

title

IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma. (English)

1 reference

http://europepmc.org/abstract/PMC/6485619

2 July 2019

author

Torsten Goldmann

11

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8 June 2020

Georgios T. Stathopoulos

17

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8 June 2020

Ioanna Giopanou

6

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8 June 2020

Theodora Agalioti

9

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8 June 2020

Vasileios Armenis

10

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8 June 2020

Sebastian Marwitz

12

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8 June 2020

Manolis Pasparakis

15

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8 June 2020

author name string

Malamati Vreka

1

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8 June 2020

Ioannis Lilis

2

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8 June 2020

Maria Papageorgopoulou

3

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8 June 2020

Georgia A Giotopoulou

4

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8 June 2020

Marina Lianou

5

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8 June 2020

Nikolaos I Kanellakis

7

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8 June 2020

Magda Spella

8

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8 June 2020

Fiona E Yull

13

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8 June 2020

Timothy S Blackwell

14

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8 June 2020

Antonia Marazioti

16

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8 June 2020

language of work or name

English

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publication date

27 March 2018

1 reference

http://europepmc.org/abstract/PMC/6485619

2 July 2019

published in

Cancer Research

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8 June 2020

volume

78

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8 June 2020

issue

11

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8 June 2020

page(s)

2939-2951

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Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis

8 June 2020

cites work

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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

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Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma

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IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

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A global double-fluorescent Cre reporter mouse

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Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis

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Host nuclear factor-kappaB activation potentiates lung cancer metastasis

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The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis

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IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

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Randomized phase II trial of docetaxel plus cetuximab or docetaxel plus bortezomib in patients with advanced non-small-cell lung cancer and a performance status of 2: CALGB 30402.

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Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation

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An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure

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17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

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FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

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Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma

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Neutralization of tumor necrosis factor bioactivity ameliorates urethane-induced pulmonary oncogenesis in mice

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12 December 2020

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

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12 December 2020

Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis

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Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

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12 December 2020

An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.

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12 December 2020

Targeting NF-κB in mouse models of lung adenocarcinoma

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12 December 2020

Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis

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Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

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Dragging ras back in the ring

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12 December 2020

An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

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12 December 2020

IKK is a therapeutic target in KRAS-Induced lung cancer with disrupted p53 activity

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Comprehensive molecular profiling of lung adenocarcinoma

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The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

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Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

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Comprehensive Evaluation of Nuclear Factor-κΒ Expression Patterns in Non-Small Cell Lung Cancer.

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The Global Burden of Cancer 2013

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Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

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Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer

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12 December 2020

Tumor-derived osteopontin isoforms cooperate with TRP53 and CCL2 to promote lung metastasis

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12 December 2020

Mutant KRAS promotes malignant pleural effusion formation

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12 December 2020

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

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12 December 2020

10.1158/0008-5472.CAN-17-1944

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29588349%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29588349%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

29588349

1 reference