Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis (Q51365355)

4 April 2018

title

Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis (English)

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4 April 2018

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Lucia Russo

1

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Hilda E Ghadieh

2

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Simona S Ghanem

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Qusai Y Al-Share

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Zachary N Smiley

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Cara Gatto-Weis

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Emily L Esakov

7

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Marcia F McInerney

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Garrett Heinrich

9

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Xin Tong

10

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Lei Yin

11

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4 April 2018

Sonia M Najjar

12

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publication date

24 October 2016

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4 April 2018

Journal of Lipid Research

published in

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4 April 2018

volume

57

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issue

12

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4 April 2018

page(s)

2163-2175

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4 April 2018

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

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PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition

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Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue

22 May 2018

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Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

22 May 2018

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Pathogenesis of selective insulin resistance in isolated hepatocytes

22 May 2018

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Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

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22 May 2018

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22 May 2018

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Interplay between FGF21 and insulin action in the liver regulates metabolism

22 May 2018

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CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH).

22 May 2018

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22 May 2018

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Hepatic insulin clearance is closely related to metabolic syndrome components

22 May 2018

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Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice

22 May 2018

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Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass

22 May 2018

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Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study

22 May 2018

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Diabetes: have we got it all wrong? Hyperinsulinism as the culprit: surgery provides the evidence

22 May 2018

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Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis

22 May 2018

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USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals

22 May 2018

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Banting lecture 2011: hyperinsulinemia: cause or consequence?

22 May 2018

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Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance

22 May 2018

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Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

22 May 2018

1 reference

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Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary report

22 May 2018

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Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice

22 May 2018

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Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism

22 May 2018

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Leptin: a molecule integrating somatic energy stores, energy expenditure and fertility

22 May 2018

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Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?

22 May 2018

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Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment

22 May 2018

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B cells: no longer bystanders in liver fibrosis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Insulin acutely decreases hepatic fatty acid synthase activity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Regulation of insulin action by CEACAM1.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

CEACAM1 regulates insulin clearance in liver

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Insulin stimulates pp120 endocytosis in cells co-expressing insulin receptors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Cloning and characterization of a functional promoter of the rat pp120 gene, encoding a substrate of the insulin receptor tyrosine kinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and i

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Roles of insulin resistance and obesity in regulation of plasma insulin concentrations.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Chronic physiologic hyperinsulinemia impairs suppression of plasma free fatty acids and increases de novo lipogenesis but does not cause dyslipidemia in conscious normal rats

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

Hyperinsulinemia of obesity is due to decreased clearance of insulin

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5321226

A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27777319

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M072066

1 reference

4 April 2018

PMC publication ID

5321226

1 reference

4 April 2018

PubMed publication ID

27777319

1 reference

4 April 2018