Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis. (Q51212780)

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20 January 2020

title

Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis (English)

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20 January 2020

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3

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20 January 2020

author name string

Seung-Beom Hong

1

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20 January 2020

Mutsuo Furihata

2

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20 January 2020

Berton Zbar

4

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20 January 2020

Laura S Schmidt

5

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20 January 2020

publication date

1 May 2006

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20 January 2020

published in

Laboratory Investigation

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20 January 2020

volume

86

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20 January 2020

issue

7

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20 January 2020

page(s)

664-675

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Identification of the von Hippel-Lindau disease tumor suppressor gene

20 January 2020

cites work

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

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Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

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The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression

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Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

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Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

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Targeting HIF-1 for cancer therapy

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

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Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

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Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

21 January 2018

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

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In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations

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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

21 January 2018

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A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action

21 January 2018

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Generalized lacZ expression with the ROSA26 Cre reporter strain

21 January 2018

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p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene

21 January 2018

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Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

21 January 2018

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Molecular and biological properties of vascular endothelial growth factor

21 January 2018

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

21 January 2018

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

21 January 2018

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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21 January 2018

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Mapping of the von Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis

21 January 2018

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