Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Q50963721)

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scientific article published on 15 June 2015

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English	Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo	scientific article published on 15 June 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

Hal E. Broxmeyer

12

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H E Broxmeyer

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Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

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W Huang

1

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Europe PubMed Central

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26 March 2018

http://europepmc.org/abstract/MED/26073084

Z Dong

2

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Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

Y Chen

3

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Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

F Wang

4

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Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

C J Wang

5

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26 March 2018

http://europepmc.org/abstract/MED/26073084

H Peng

6

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Europe PubMed Central

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26 March 2018

http://europepmc.org/abstract/MED/26073084

Y He

7

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26 March 2018

http://europepmc.org/abstract/MED/26073084

G Hangoc

8

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26 March 2018

http://europepmc.org/abstract/MED/26073084

K Pollok

9

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26 March 2018

http://europepmc.org/abstract/MED/26073084

G Sandusky

10

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26 March 2018

http://europepmc.org/abstract/MED/26073084

X-Y Fu

11

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26 March 2018

http://europepmc.org/abstract/MED/26073084

Z-Y Zhang

13

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26 March 2018

http://europepmc.org/abstract/MED/26073084

J-Y Liu

14

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26 March 2018

http://europepmc.org/abstract/MED/26073084

J-T Zhang

15

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26 March 2018

http://europepmc.org/abstract/MED/26073084

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publication date

15 June 2015

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Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

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Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

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26 March 2018

http://europepmc.org/abstract/MED/26073084

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26 March 2018

http://europepmc.org/abstract/MED/26073084

783-792

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26 March 2018

http://europepmc.org/abstract/MED/26073084

The role of STATs in transcriptional control and their impact on cellular function

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

STAT3: a critical transcription activator in angiogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

STAT3 as a central regulator of tumor metastases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Stat3 as an oncogene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Small molecule inhibitors of Stat3 signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

DNA-binding small molecules as inhibitors of transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Loss of 14-3-3sigma in prostate cancer and its precursors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

21 January 2018

Prognostic significance of p-STAT3 in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

31 March 2020

Targeting STAT3 in cancer: how successful are we?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

31 March 2020

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.215

31 March 2020

STAT3: a target to enhance antitumor immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/26073084

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26073084

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26073084

12 December 2020

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Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/26073084

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2015.215

1 reference

Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 March 2018

http://europepmc.org/abstract/MED/26073084

ResearchGate publication ID

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