Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers (Q50525085)

14 March 2018

title

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers (English)

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14 March 2018

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6

William L Klein

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14 March 2018

author name string

Tomohiro Umeda

1

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Kenjiro Ono

2

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Ayumi Sakai

3

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Minato Yamashita

4

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Mineyuki Mizuguchi

5

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Masahito Yamada

7

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Hiroshi Mori

8

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Takami Tomiyama

9

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language of work or name

English

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publication date

28 March 2016

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14 March 2018

published in

Brain

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volume

139

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issue

Pt 5

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14 March 2018

page(s)

1568-1586

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Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity

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Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils

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Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial.

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α‐Synuclein oligomers oppose long‐term potentiation and impair memory through a calcineurin‐dependent mechanism: relevance to human synucleopathic diseases

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The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells

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The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux

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Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

21 January 2018

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Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

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Structure-neurotoxicity relationships of amyloid beta-protein oligomers

21 January 2018

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Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

21 January 2018

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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice

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Is there still any hope for amyloid-based immunotherapy for Alzheimer's disease?

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Testing the right target and right drug at the right stage

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

21 January 2018

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Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophy

21 January 2018

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Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

21 January 2018

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Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice

21 January 2018

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Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

21 January 2018

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Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice

21 January 2018

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Targeting autophagy in neurodegenerative diseases

21 January 2018

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Tau aggregation is driven by a transition from random coil to beta sheet structure

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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Rifampicin protects PC12 cells against MPP+-induced apoptosis and inhibits the expression of an alpha-Synuclein multimer

21 January 2018

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Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWW042

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14 March 2018

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14 March 2018