MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome (Q50493756)

14 March 2018

http://europepmc.org/abstract/MED/27498868

title

MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome (English)

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14 March 2018

http://europepmc.org/abstract/MED/27498868

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Xixi Zhang

1

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12 June 2020

Cunxian Fan

2

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12 June 2020

Haiwei Zhang

3

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12 June 2020

Qun Zhao

4

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12 June 2020

Yongbo Liu

5

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12 June 2020

Chengxian Xu

6

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12 June 2020

Qun Xie

7

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12 June 2020

Xiaoxia Wu

8

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12 June 2020

Xianjun Yu

9

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12 June 2020

Jianke Zhang

10

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12 June 2020

Haibing Zhang

11

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12 June 2020

publication date

3 August 2016

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14 March 2018

http://europepmc.org/abstract/MED/27498868

published in

Cell Reports

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12 June 2020

volume

16

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12 June 2020

issue

12

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12 June 2020

page(s)

3247-3259

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RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

12 June 2020

cites work

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12 December 2020

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12 December 2020

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

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12 December 2020

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

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12 December 2020

Death receptor signal transducers: nodes of coordination in immune signaling networks

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12 December 2020

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

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12 December 2020

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

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12 December 2020

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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12 December 2020

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

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12 December 2020

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

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12 December 2020

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

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12 December 2020

Caspase-8 serves both apoptotic and nonapoptotic roles

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12 December 2020

T cell-specific FADD-deficient mice: FADD is required for early T cell development

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12 December 2020

A novel function of RIP1 in postnatal development and immune homeostasis by protecting against RIP3-dependent necroptosis and FADD-mediated apoptosis

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12 December 2020

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

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12 December 2020

Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart

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12 December 2020

Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

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12 December 2020

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

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12 December 2020

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

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12 December 2020

Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice

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12 December 2020

Functional complementation between FADD and RIP1 in embryos and lymphocytes

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12 December 2020

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

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12 December 2020

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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12 December 2020

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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12 December 2020

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

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12 December 2020

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

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12 December 2020

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

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12 December 2020

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

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12 December 2020

A plug release mechanism for membrane permeation by MLKL.

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12 December 2020

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

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12 December 2020

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

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12 December 2020

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

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12 December 2020

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

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12 December 2020

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

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12 December 2020

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

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12 December 2020

Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice

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12 December 2020

A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis

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12 December 2020

Antigen-mediated T cell expansion regulated by parallel pathways of death

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12 December 2020

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

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12 December 2020

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

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12 December 2020

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

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12 December 2020

Mechanism of NLRP3 inflammasome activation

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12 December 2020

Apoptosis by death factor

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12 December 2020

Activation and regulation of the inflammasomes

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12 December 2020

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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12 December 2020

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

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12 December 2020

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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12 December 2020

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

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12 December 2020

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

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12 December 2020

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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12 December 2020

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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12 December 2020

The diverse role of RIP kinases in necroptosis and inflammation

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12 December 2020

10.1016/J.CELREP.2016.06.103

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27498868%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27498868%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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