Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. (Q50335834)

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6 January 2020

title

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 (English)

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6 January 2020

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6

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6 January 2020

Osamu Takeuchi

9

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6 January 2020

author name string

Tatsukata Kawagoe

1

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6 January 2020

Shintaro Sato

2

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Kazufumi Matsushita

3

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Hiroki Kato

4

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Kosuke Matsui

5

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6 January 2020

Tatsuya Saitoh

7

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Taro Kawai

8

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Shizuo Akira

10

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language of work or name

English

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publication date

27 April 2008

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6 January 2020

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6 January 2020

volume

9

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issue

6

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page(s)

684-691

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Pathogen recognition and innate immunity

6 January 2020

cites work

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Innate immune recognition

21 January 2018

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Inferences, questions and possibilities in Toll-like receptor signalling

21 January 2018

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

21 January 2018

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

21 January 2018

1 reference

TIRAP: an adapter molecule in the Toll signaling pathway

21 January 2018

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

21 January 2018

1 reference

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

21 January 2018

1 reference

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

21 January 2018

1 reference

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

21 January 2018

1 reference

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

21 January 2018

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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

21 January 2018

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TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

21 January 2018

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Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

21 January 2018

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

21 January 2018

1 reference

IL-1R-Associated Kinase 4 Is Required for Lipopolysaccharide- Induced Activation of APC

21 January 2018

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Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

21 January 2018

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IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression

21 January 2018

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A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

21 January 2018

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

21 January 2018

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

21 January 2018

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Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex

21 January 2018

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Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses

21 January 2018

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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

21 January 2018

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IRAK-M is a negative regulator of Toll-like receptor signaling

21 January 2018

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NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity.

21 January 2018

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Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

21 January 2018

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

21 January 2018

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

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The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory

21 January 2018

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IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

21 January 2018

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IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

21 January 2018

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Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

21 January 2018

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IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

21 January 2018

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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

21 January 2018

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Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity

21 January 2018

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Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-κB

21 January 2018

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IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)

21 January 2018

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IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

21 January 2018

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PEST sequences and regulation by proteolysis

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways

21 January 2018

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

21 January 2018

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Unresponsiveness of MyD88-deficient mice to endotoxin

21 January 2018

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7 January 2021

The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation

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7 January 2021

Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB

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7 January 2021

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

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7 January 2021

Identifiers

DOI

10.1038/NI.1606

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18438411%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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