A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing (Q50037033)

http://europepmc.org/abstract/PMC/5830921

22 June 2018

title

A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing (English)

1 reference

http://europepmc.org/abstract/PMC/5830921

22 June 2018

author

Nicolas L Fawzi

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Mandar Naik

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Tanja Mittag

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

Ailin Wang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Alexander E Conicella

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Hermann Broder Schmidt

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Erik W Martin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Shannon N Rhoads

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ashley N Reeb

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Amanda Nourse

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Daniel Ramirez Montero

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Veronica H Ryan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Rajat Rohatgi

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Frank Shewmaker

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Yuna M Ayala

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

0 references

publication date

9 February 2018

1 reference

http://europepmc.org/abstract/PMC/5830921

22 June 2018

published in

The EMBO Journal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

3 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5830921/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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24 June 2018

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24 June 2018

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24 June 2018

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24 June 2018

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24 June 2018

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24 June 2018

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24 June 2018

1 reference

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24 June 2018

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24 June 2018

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Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

24 June 2018

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

24 June 2018

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24 June 2018

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24 June 2018

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24 June 2018

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TDP-43 dimerizes in human cells in culture.

24 June 2018

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24 June 2018

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TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

24 June 2018

1 reference

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Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

24 June 2018

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Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

24 June 2018

1 reference

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The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

24 June 2018

1 reference

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

24 June 2018

1 reference

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24 June 2018

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

24 June 2018

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24 June 2018

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24 June 2018

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24 June 2018

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Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

24 June 2018

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Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

24 June 2018

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

24 June 2018

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24 June 2018

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24 June 2018

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Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment.

24 June 2018

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The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding.

14 August 2018

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Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function

14 August 2018

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Inter-domain interactions of TDP-43 as decoded by NMR.

14 August 2018

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TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation.

14 August 2018

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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

14 August 2018

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Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.

14 August 2018

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Germline P granules are liquid droplets that localize by controlled dissolution/condensation

14 August 2018

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TDP43 depletion rescues aberrant CFTR exon 9 skipping

14 August 2018

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Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function

14 August 2018

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Docking of protein-protein complexes on the basis of highly ambiguous intermolecular distance restraints derived from 1H/15N chemical shift mapping and backbone 15N-1H residual dipolar couplings using conjoined rigid body/torsion angle dynamics.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5830921

Internal coordinates for molecular dynamics and minimization in structure determination and refinement.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5830921

The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29438978

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201797452

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438978%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

29438978

1 reference