HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance (Q49571851)

21 February 2018

title

HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance (English)

1 reference

21 February 2018

1 reference

Shou Liu

1

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21 February 2018

Ji Shin Lee

2

1 reference

21 February 2018

Chunfa Jie

3

1 reference

21 February 2018

Min-Ho Park

4

1 reference

21 February 2018

Yoichiro Iwakura

5

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21 February 2018

Yogin Patel

6

1 reference

21 February 2018

Mithil Soni

7

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21 February 2018

David Reisman

8

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21 February 2018

Hexin Chen

9

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21 February 2018

language of work or name

English

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publication date

30 January 2018

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21 February 2018

published in

Cancer Research

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21 February 2018

Alarmins: Feel the Stress.

cites work

1 reference

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HER2 intratumoral heterogeneity analyses by concurrent HER2 gene and protein assessment for the prognosis of HER2 negative invasive breast cancer patients

26 August 2018

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Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade

26 August 2018

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Expression distribution of cancer stem cells, epithelial to mesenchymal transition, and telomerase activity in breast cancer and their association with clinicopathologic characteristics

26 August 2018

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Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

26 August 2018

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HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab.

26 August 2018

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Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98

26 August 2018

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Cancer stem cells and cells of origin in MMTV-Her2/neu-induced mammary tumorigenesis.

26 August 2018

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Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling.

26 August 2018

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PKCδ-Induced PU.1 Phosphorylation Promotes Hematopoietic Stem Cell Differentiation to Dendritic Cells

26 August 2018

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HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis

26 August 2018

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Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

26 August 2018

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Sterile inflammation: sensing and reacting to damage

26 August 2018

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HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial

26 August 2018

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Immunity, Inflammation, and Cancer

26 August 2018

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Interleukin-1 (IL-1) pathway

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Cancer-related inflammation

26 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

The CD44+/CD24- phenotype is enriched in basal-like breast tumors

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

let-7 regulates self renewal and tumorigenicity of breast cancer cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

26 August 2018

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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

26 August 2018

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A trimeric anti-HER2/neu ScFv and tumor necrosis factor-alpha fusion protein induces HER2/neu signaling and facilitates repair of injured epithelia

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Toll-like receptor signalling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Phosphorylation and regulation of Raf by Akt (protein kinase B)

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Induction of NF-kappaB by the Akt/PKB kinase

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5899630

Amplification of c-erbB-2 and aggressive human breast tumors?

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29382706

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Stem Cells and Cancer: Two Faces of Eve

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29382706

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HER2 status and benefit from adjuvant trastuzumab in breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29382706

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-17-2761

1 reference

21 February 2018

PMC publication ID

5899630

0 references

1 reference

21 February 2018