Toll-like receptors as molecular switches (Q48546511)

12 February 2018

review article

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title

Toll-like receptors as molecular switches (English)

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12 February 2018

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2

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12 February 2018

author name string

Nicholas J Gay

series ordinal

1

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12 February 2018

Alexander N R Weber

series ordinal

3

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12 February 2018

publication date

18 August 2006

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Nature Reviews Immunology

published in

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12 February 2018

volume

6

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12 February 2018

issue

9

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12 February 2018

page(s)

693-698

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12 February 2018

Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein

cites work

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A conserved signaling pathway: the Drosophila toll-dorsal pathway

21 January 2018

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Toll-like receptor signalling

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Toll-like receptor control of the adaptive immune responses

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Sepsis and evolution of the innate immune response

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A family of human receptors structurally related to Drosophila Toll

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Structural and functional diversity in the leucine-rich repeat family of proteins

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Structure of human follicle-stimulating hormone in complex with its receptor

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Identification of a functional epitope of the Nogo receptor by a combinatorial approach using ribosome display

31 March 2020

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Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate

31 March 2020

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Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

31 March 2020

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Essential role of MD-2 in LPS responsiveness and TLR4 distribution

31 March 2020

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ML -- a conserved domain involved in innate immunity and lipid metabolism

31 March 2020

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MD-2: the Toll 'gatekeeper' in endotoxin signalling

31 March 2020

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Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

31 March 2020

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Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway.

31 March 2020

1 reference

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

31 March 2020

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Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo

31 March 2020

1 reference

Multimerization and interaction of Toll and Spätzle in Drosophila

31 March 2020

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

31 March 2020

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Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

31 March 2020

1 reference

The structural basis of negative cooperativity: receptors and enzymes

31 March 2020

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Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

31 March 2020

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Structure of nerve growth factor complexed with the shared neurotrophin receptor p75

31 March 2020

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The molecular structure of the Toll-like receptor 3 ligand-binding domain.

31 March 2020

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Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

31 March 2020

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Pathogen recognition: TLRs throw us a curve

31 March 2020

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The dsRNA binding site of human Toll-like receptor 3.

31 March 2020

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The Toll-IL-1 receptor adaptor family grows to five members.

31 March 2020

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

31 March 2020

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Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

31 March 2020

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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

31 March 2020

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Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains

31 March 2020

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

31 March 2020

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An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2

31 March 2020

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Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets

31 March 2020

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Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

31 March 2020

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

31 March 2020

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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

31 March 2020

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

31 March 2020

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Leucine-rich repeats and pathogen recognition in Toll-like receptors.

31 March 2020

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Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling

31 March 2020

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TLR9 signals after translocating from the ER to CpG DNA in the lysosome

31 March 2020

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Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

31 March 2020

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

31 March 2020

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Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

31 March 2020

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Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

31 March 2020

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

31 March 2020

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Crystal structures of two plasmid copy control related RNA duplexes: An 18 base pair duplex at 1.20 A resolution and a 19 base pair duplex at 1.55 A resolution

31 March 2020

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Getting knotted: a model for the structure and activation of Spätzle.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1916

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12 February 2018

Dimensions Publication ID

1020708954

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12 February 2018