Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA). (Q47827360)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29016853%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

title

Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA) (English)

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6 April 2020

main subject

spinal muscular atrophy

1 reference

1 reference

1

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6 April 2020

Bert M Verheijen

2

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6 April 2020

Gamze Bora

5

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6 April 2020

author name string

Niko Hensel

3

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6 April 2020

Miriam Peters

4

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6 April 2020

Gudrun Brandes

6

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6 April 2020

Renata Vieira de Sá

7

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6 April 2020

Natascha Heidrich

8

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6 April 2020

Silke Fischer

9

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6 April 2020

Hella Brinkmann

10

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6 April 2020

W Ludo van der Pol

11

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6 April 2020

Brunhilde Wirth

12

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6 April 2020

R Jeroen Pasterkamp

13

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6 April 2020

Peter Claus

14

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6 April 2020

publication date

1 October 2017

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6 April 2020

published in

Human Molecular Genetics

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6 April 2020

volume

26

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6 April 2020

issue

20

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6 April 2020

page(s)

3946-3959

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Investigational therapies for the treatment of spinal muscular atrophy.

6 April 2020

cites work

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21 January 2018

Spinal muscular atrophy

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Identification and characterization of a spinal muscular atrophy-determining gene

21 January 2018

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At the "junction" of spinal muscular atrophy pathogenesis: the role of neuromuscular junction dysfunction in SMA disease progression.

21 January 2018

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SMN, profilin IIa and plastin 3: a link between the deregulation of actin dynamics and SMA pathogenesis.

21 January 2018

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The spinal muscular atrophy gene product regulates neurite outgrowth: importance of the C terminus.

21 January 2018

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The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.

21 January 2018

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Bilateral crosstalk of rho- and extracellular-signal-regulated-kinase (ERK) pathways is confined to an unidirectional mode in spinal muscular atrophy (SMA).

21 January 2018

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Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy

21 January 2018

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Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons

21 January 2018

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The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development

21 January 2018

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VEGFR2 (KDR/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain

21 January 2018

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Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development.

21 January 2018

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Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy

21 January 2018

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A mouse model for spinal muscular atrophy

21 January 2018

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Expression patterns of plexins and neuropilins are consistent with cooperative and separate functions during neural development

21 January 2018

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PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis

21 January 2018

1 reference

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The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality.

21 January 2018

1 reference

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Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

21 January 2018

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Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

21 January 2018

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Results from a phase 1 study of nusinersen (ISIS-SMN(Rx)) in children with spinal muscular atrophy

21 January 2018

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Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience

21 January 2018

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Isolation and characterization of cytoplasmic cofilin-actin rods

21 January 2018

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In vitro analysis of rod composition and actin dynamics in inherited myopathies.

21 January 2018

1 reference

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Formation of actin-ADF/cofilin rods transiently retards decline of mitochondrial potential and ATP in stressed neurons

21 January 2018

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Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function

21 January 2018

1 reference

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Cofilin aggregation blocks intracellular trafficking and induces synaptic loss in hippocampal neurons

21 January 2018

1 reference

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Actin dynamics and cofilin-actin rods in alzheimer disease

21 January 2018

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Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells

21 January 2018

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Incorporation of cofilin into rods depends on disulfide intermolecular bonds: implications for actin regulation and neurodegenerative disease

21 January 2018

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Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion

21 January 2018

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Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

21 January 2018

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Functional regulation of semaphorin receptors by proprotein convertases

21 January 2018

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Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model.

21 January 2018

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RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability

21 January 2018

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Getting neural circuits into shape with semaphorins

21 January 2018

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Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition

21 January 2018

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Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling

21 January 2018

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Early Functional Impairment of Sensory-Motor Connectivity in a Mouse Model of Spinal Muscular Atrophy

21 January 2018

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Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction

21 January 2018

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PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development

21 January 2018

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Congenital heart disease is a feature of severe infantile spinal muscular atrophy

21 January 2018

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Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects

21 January 2018

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Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect

21 January 2018

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Systemic, postsymptomatic antisense oligonucleotide rescues motor unit maturation delay in a new mouse model for type II/III spinal muscular atrophy

21 January 2018

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Digital necroses and vascular thrombosis in severe spinal muscular atrophy

21 January 2018

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Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.

21 January 2018

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Actin-Interacting Protein 1 Contributes to Intranuclear Rod Assembly in Dictyostelium discoideum.

21 January 2018

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Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis

21 January 2018

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RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress

21 January 2018

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Motor neuron mitochondrial dysfunction in spinal muscular atrophy

21 January 2018

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Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.

21 January 2018

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SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons

21 January 2018

1 reference

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Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers

21 January 2018

1 reference

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Implication of matrix metalloproteinases in regulating neuronal disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Tissue deformation spatially modulates VEGF signaling and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Analyzing real-time PCR data by the comparative C(T) method

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX282

21 January 2018

Identifiers

DOI

10.1093/HMG/DDX282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29016853%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

1 reference