Naturally Occurring Amino Acids in Helix 10 of the Thyroid Hormone Receptor Mediate Isoform-Specific TH Gene Regulation (Q47801172)

5 February 2018

title

Naturally Occurring Amino Acids in Helix 10 of the Thyroid Hormone Receptor Mediate Isoform-Specific TH Gene Regulation (English)

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5 February 2018

author name string

Vitor M S Pinto

1

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5 February 2018

Svetlana Minakhina

2

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5 February 2018

Shuiqing Qiu

3

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5 February 2018

Aniket Sidhaye

4

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5 February 2018

Michael P Brotherton

5

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5 February 2018

Amy Suhotliv

6

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5 February 2018

Fredric E Wondisford

7

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5 February 2018

language of work or name

English

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publication date

1 September 2017

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5 February 2018

published in

Endocrinology

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5 February 2018

volume

158

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5 February 2018

issue

9

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5 February 2018

page(s)

3067-3078

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5 February 2018

Resistance to thyroid hormone due to defective thyroid receptor alpha

cites work

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Thyroid hormone receptors and resistance to thyroid hormone disorders

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Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver

26 August 2018

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Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding

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A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2.

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The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons

26 August 2018

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Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function.

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Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation

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Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor

26 August 2018

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Association between an R338L mutation in the thyroid hormone receptor-beta gene and thyrotoxic features in two unrelated kindreds with resistance to thyroid hormone.

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Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone

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Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance.

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Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo

26 August 2018

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Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini

26 August 2018

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Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor

26 August 2018

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Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers

26 August 2018

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A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene

26 August 2018

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Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

26 August 2018

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Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system

26 August 2018

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Quantitation of rat tissue thyroid hormone binding receptor isoforms by immunoprecipitation of nuclear triiodothyronine binding capacity

26 August 2018

1 reference

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Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5659674

The N-Terminal A/B Domain of the Thyroid Hormone Receptor-β2 Isoform Influences Ligand-Dependent Recruitment of Coactivators to the Ligand-Binding Domain

26 August 2018

1 reference

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Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function

1 December 2018

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12 December 2020

Thyroid hormone response element organization dictates the composition of active receptor

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12 December 2020

The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements

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12 December 2020

A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition

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12 December 2020

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers

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12 December 2020

Identifiers

DOI

10.1210/EN.2017-00314

1 reference

5 February 2018

PMC publication ID

5659674

0 references

1 reference

5 February 2018