Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets (Q47569499)

4 February 2018

title

Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets (English)

1 reference

4 February 2018

genome-wide association study

1 reference

1 reference

based on heuristic

inferred from title

author

Katri Räikkönen-Talvitie

17

1 reference

4 February 2018

Neil Pendleton

55

1 reference

4 February 2018

Jari Lahti

58

1 reference

4 February 2018

Astri J. Lundervold

Astri J Lundervold

14

0 references

Robert M Bilder

Robert M Bilder

38

0 references

Ian Deary

Ian J Deary

62

0 references

Daniel R. Weinberger

54

Daniel R Weinberger

1 reference

4 February 2018

42

Russell A Poldrack

1 reference

4 February 2018

Srdjan Djurovic

8

0 references

Ingrid Melle

9

Ingrid Melle

1 reference

4 February 2018

10

Kjetil Sundet

1 reference

4 February 2018

19

Aarno Palotie

1 reference

4 February 2018

61

Ole A Andreassen

1 reference

4 February 2018

12

Ivar Reinvang

1 reference

4 February 2018

44

Eliza Congdon

1 reference

4 February 2018

24

Stella Giakoumaki

1 reference

4 February 2018

41

Edythe London

1 reference

4 February 2018

21

Ina Giegling

1 reference

4 February 2018

57

Dan Rujescu

1 reference

4 February 2018

Tyrone Cannon

40

Tyrone D Cannon

1 reference

4 February 2018

Katherine E Burdick

25

Katherine E Burdick

1 reference

4 February 2018

Dave Liewald

6

David C Liewald

1 reference

4 February 2018

David C. Glahn

63

David C Glahn

1 reference

4 February 2018

Johan G. Eriksson

20

Johan G Eriksson

1 reference

4 February 2018

Thomas Espeseth

16

Thomas Espeseth

1 reference

4 February 2018

Vidar M Steen

15

Vidar M Steen

1 reference

4 February 2018

Derek W. Morris

50

Derek Morris

1 reference

4 February 2018

Matthew C Keller

60

Matthew C Keller

1 reference

4 February 2018

Gary J. Donohoe

49

Gary Donohoe

1 reference

4 February 2018

Joey W. Trampush

2

Joey W Trampush

1 reference

4 February 2018

John M Starr

7

John M Starr

1 reference

4 February 2018

Anna C. Need

30

Anna C Need

1 reference

4 February 2018

Elizabeth T Cirulli

31

Elizabeth T Cirulli

1 reference

4 February 2018

Dimitrios G Avramopoulos

34

Dimitrios Avramopoulos

1 reference

4 February 2018

Dan E Arking

36

Dan E Arking

1 reference

4 February 2018

Nelson A. Freimer

39

Nelson A Freimer

1 reference

4 February 2018

Fred W Sabb

43

Fred W Sabb

1 reference

4 February 2018

Matthew A Scult

46

Matthew A Scult

1 reference

4 February 2018

Richard E Straub

48

Richard E Straub

1 reference

4 February 2018

Bettina Konte

22

Bettina Konte

1 reference

4 February 2018

Andrea Christoforou

11

Andrea Christoforou

1 reference

4 February 2018

Deborah Attix

29

Deborah K Attix

1 reference

4 February 2018

Panos Roussos

23

Panos Roussos

1 reference

4 February 2018

William Ollier

27

William Ollier

1 reference

4 February 2018

Aiden Corvin

51

Aiden Corvin

1 reference

4 February 2018

Max Lam

1

Max Lam

1 reference

4 February 2018

Pamela DeRosse

13

Pamela DeRosse

1 reference

4 February 2018

Antony Payton

26

Antony Payton

1 reference

4 February 2018

Ornit Chiba-Falek

28

Ornit Chiba-Falek

1 reference

4 February 2018

Aristotle Voineskos

32

Aristotle N Voineskos

1 reference

4 February 2018

Alex Hatzimanolis

35

Alex Hatzimanolis

1 reference

4 February 2018

Nikolaos Smyrnis

37

Nikolaos Smyrnis

1 reference

4 February 2018

Panos Bitsios

56

Panos Bitsios

1 reference

4 February 2018

Stephanie Le Hellard

59

Stephanie Le Hellard

1 reference

4 February 2018

Emily Drabant Conley

45

Emily Drabant Conley

1 reference

4 February 2018

65

Todd Lencz

1 reference

4 February 2018

Jin Yu

3

1 reference

4 February 2018

Emma Knowles

4

1 reference

4 February 2018

Gail Davies

5

1 reference

4 February 2018

Elisabeth Widen

18

1 reference

4 February 2018

Nikos C Stefanis

33

1 reference

4 February 2018

Dwight Dickinson

47

1 reference

4 February 2018

Michael Gill

52

1 reference

4 February 2018

Ahmad R Hariri

53

1 reference

4 February 2018

Anil K Malhotra

64

1 reference

4 February 2018

publication date

1 November 2017

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4 February 2018

published in

Cell Reports

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4 February 2018

volume

21

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4 February 2018

issue

9

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4 February 2018

page(s)

2597-2613

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4 February 2018

Drug enrichment and discovery from schizophrenia genome-wide association results: an analysis and visualisation approach

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

The Cerebellum: Adaptive Prediction for Movement and Cognition.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Novel genetic loci underlying human intracranial volume identified through genome-wide association

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

A reference panel of 64,976 haplotypes for genotype imputation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

On TADs and LADs: Spatial Control Over Gene Expression.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

The Ensembl Variant Effect Predictor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genome-wide association study identifies 74 loci associated with educational attainment

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genetic studies in intellectual disability and related disorders

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

A global reference for human genetic variation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

An atlas of genetic correlations across human diseases and traits

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

The support of human genetic evidence for approved drug indications

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

MAGMA: generalized gene-set analysis of GWAS data

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Celsr3 and Fzd3 in axon guidance

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genetic studies of body mass index yield new insights for obesity biology

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

PRSice: Polygenic Risk Score software

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

A Double-Blind, Placebo-Controlled Comparator Study of LY2140023 monohydrate in patients with schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genetics and intelligence differences: five special findings.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genetic variability in the regulation of gene expression in ten regions of the human brain

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Biological insights from 108 schizophrenia-associated genetic loci

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Quality control and conduct of genome-wide association meta-analyses

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Validating therapeutic targets through human genetics

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Implication of a rare deletion at distal 16p11.2 in schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Cognitive impairment in schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101: enhancement of long-term potentiation and CaMKII autophosphorylation in rat cortical slices

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

A copy number variation morbidity map of developmental delay

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genome-wide association studies establish that human intelligence is highly heritable and polygenic

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

The MATRICS consensus cognitive battery in patients with bipolar I disorder.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Current research on cognitive aspects of anxiety disorders

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Myelin lesions associated with lysosomal and peroxisomal disorders

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Family background buys an education in Minnesota but not in Sweden

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

METAL: fast and efficient meta-analysis of genomewide association scans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genetic foundations of human intelligence

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Genome-wide association analysis identifies 20 loci that influence adult height

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Many sequence variants affecting diversity of adult human height

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Role of class 3 semaphorins in the development and maturation of the septohippocampal pathway.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789458

Functional mapping and annotation of genetic associations with FUMA.

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29186694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29186694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2017.11.028

1 reference

4 February 2018

PMC publication ID

5789458

1 reference

4 February 2018

PubMed publication ID

29186694

1 reference

4 February 2018