Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy (Q46902534)

26 December 2017

title

Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy (English)

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26 December 2017

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Justin Lecher

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Matthias Stoldt

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Lothar Gremer

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Dieter Willbold

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author name string

Na Sun

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Susanne Aileen Funke

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Hans-Henning Ludwig

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Hans-Ulrich Demuth

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Martin Kleinschmidt

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publication date

24 September 2012

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Journal of Peptide Science

published in

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volume

18

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issue

11

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page(s)

691-695

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describes a project that uses

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The toxicity in vitro of beta-amyloid protein

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Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

21 January 2018

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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

21 January 2018

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Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery

21 January 2018

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The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

21 January 2018

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N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42.

21 January 2018

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Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

21 January 2018

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Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

21 January 2018

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Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide

21 January 2018

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Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation.

21 January 2018

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Theoretical models of the ion channel structure of amyloid beta-protein

21 January 2018

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Alzheimer's disease: soluble oligomeric Abeta(1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies

21 January 2018

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Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

21 January 2018

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Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease

21 January 2018

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Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease

21 January 2018

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Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain

21 January 2018

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Conformational solution studies of the SDS micelle-bound 11-28 fragment of two Alzheimer's beta-amyloid variants (E22K and A21G) using CD, NMR, and MD techniques

21 January 2018

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Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide

21 January 2018

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Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

21 January 2018

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Random coil chemical shifts in acidic 8 M urea: implementation of random coil shift data in NMRView

21 January 2018

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Sequence-dependent correction of random coil NMR chemical shifts

21 January 2018

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Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

21 January 2018

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

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The CCPN data model for NMR spectroscopy: development of a software pipeline

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PSC.2456

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26 December 2017

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26 December 2017