Tumor suppressor WWOX moderates the mitochondrial respiratory complex. (Q46666593)

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24 February 2020

title

Tumor suppressor WWOX moderates the mitochondrial respiratory complex (English)

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24 February 2020

4

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24 February 2020

Amanda Choo

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24 February 2020

Donna Denton

8

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24 February 2020

author name string

Louise V O'Keefe

2

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24 February 2020

Cheng Shoou Lee

3

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24 February 2020

Zeeshan Shaukat

5

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24 February 2020

Alexander Colella

6

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24 February 2020

Kristie Lee

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24 February 2020

Robert I Richards

9

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publication date

22 September 2015

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Genes, Chromosomes and Cancer

24 February 2020

published in

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24 February 2020

volume

54

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24 February 2020

issue

12

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24 February 2020

page(s)

745-761

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The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration

24 February 2020

cites work

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Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks

21 January 2018

1 reference

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response

21 January 2018

1 reference

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation.

21 January 2018

1 reference

Loss of dE2F compromises mitochondrial function

21 January 2018

1 reference

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

21 January 2018

1 reference

Targeted deletion of Wwox reveals a tumor suppressor function

21 January 2018

1 reference

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism

21 January 2018

1 reference

Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis

21 January 2018

1 reference

The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability.

21 January 2018

1 reference

Activation of AKT kinases in cancer: implications for therapeutic targeting

21 January 2018

1 reference

Signatures of mutation and selection in the cancer genome

21 January 2018

1 reference

21 January 2018

1 reference

Mitochondrial defects in cancer

21 January 2018

1 reference

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

21 January 2018

1 reference

JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis

21 January 2018

1 reference

Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidoreductase in vivo

21 January 2018

1 reference

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

21 January 2018

1 reference

Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells.

21 January 2018

1 reference

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

21 January 2018

1 reference

Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors

21 January 2018

1 reference

Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches.

21 January 2018

1 reference

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

21 January 2018

1 reference

Very large common fragile site genes and their potential role in cancer development

21 January 2018

1 reference

WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications

21 January 2018

1 reference

FOXO transcription factors at the interface between longevity and tumor suppression

21 January 2018

1 reference

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

A map of WW domain family interactions

21 January 2018

1 reference

WWOX induces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721.

21 January 2018

1 reference

The WWOX gene modulates high-density lipoprotein and lipid metabolism

21 January 2018

1 reference

Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression

21 January 2018

1 reference

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

21 January 2018

1 reference

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes

21 January 2018

1 reference

Characterization of the structure and function of W --> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding

21 January 2018

1 reference

Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin

21 January 2018

1 reference

Expression of Drosophila FOXO regulates growth and can phenocopy starvation

21 January 2018

1 reference

Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

1 reference

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

21 January 2018

1 reference

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene

21 January 2018

1 reference

Retracted: Mitochondrial Dysfunction Promotes Breast Cancer Cell Migration and Invasion through HIF1α Accumulation via Increased Production of Reactive Oxygen Species

21 January 2018

1 reference

Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox

21 January 2018

1 reference

The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation

21 January 2018

1 reference

Mutation of tyrosine-194 and lysine-198 in the catalytic site of pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase

21 January 2018

1 reference

Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species

21 January 2018

1 reference

Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions

21 January 2018

1 reference

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

21 January 2018

1 reference

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

21 January 2018

1 reference

WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis

21 January 2018

1 reference

Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review

21 January 2018

1 reference

Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

21 January 2018

1 reference

A role for the WWOX gene in prostate cancer

21 January 2018

1 reference

The role of hypoxia-inducible factors in tumorigenesis.

21 January 2018

1 reference

Fragile and unstable chromosomes in cancer: causes and consequences

21 January 2018

1 reference

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer

21 January 2018

1 reference

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

21 January 2018

1 reference

Cellular and developmental adaptations to hypoxia: a Drosophila perspective.

21 January 2018

1 reference

WWOX gene is associated with HDL cholesterol and triglyceride levels.

21 January 2018

1 reference

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.

21 January 2018

1 reference

WWOX: a fragile tumor suppressor

21 January 2018

1 reference

HIF-1 and tumor progression: pathophysiology and therapeutics

21 January 2018

1 reference

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

21 January 2018

1 reference

A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy.

21 January 2018

1 reference

Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness.

21 January 2018

1 reference

Tumor suppressor genes and ROS: complex networks of interactions

21 January 2018

1 reference

21 January 2018

Mitochondria and cancer

1 reference

Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila

21 January 2018

1 reference

Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people.

21 January 2018

1 reference

WWOX expression in colorectal cancer—a real-time quantitative RT-PCR study

21 January 2018

1 reference

21 January 2018

Mitochondrial disorders

1 reference

Evidences that the polymorphism Pro-282-Ala within the tumor suppressor gene WWOX is a new risk factor for differentiated thyroid carcinoma

21 January 2018

1 reference

7 January 2021

The role of the WWOX gene in leukemia and its mechanisms of action

1 reference

7 January 2021

FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila

1 reference

7 January 2021

A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese

1 reference

7 January 2021