Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene (Q46284220)

21 December 2017

title

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene (English)

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21 December 2017

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21 December 2017

author name string

Jesus Perez-Losada

2

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21 December 2017

Di Wu

3

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21 December 2017

Reyno Delrosario

4

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21 December 2017

Ryosuke Tsunematsu

5

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21 December 2017

Keiichi I Nakayama

6

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21 December 2017

Ken Brown

7

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21 December 2017

Sheila Bryson

8

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21 December 2017

Allan Balmain

9

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21 December 2017

language of work or name

English

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publication date

1 December 2004

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21 December 2017

published in

Nature

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21 December 2017

volume

432

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21 December 2017

issue

7018

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21 December 2017

page(s)

775-779

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21 December 2017

Inactivation of hCDC4 can cause chromosomal instability

cites work

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Analysis of trk A and p53 association

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

The p53MH algorithm and its application in detecting p53-responsive genes

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Expression of constitutively active Notch4 (Int-3) modulates myeloid proliferation and differentiation and promotes expansion of hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

High metastatic potential in mice inheriting a targeted p53 missense mutation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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https://api.crossref.org/works/10.1038%2FNATURE03155

7 January 2021

Identifiers

DOI

10.1038/NATURE03155

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21 December 2017

Dimensions Publication ID

1017362841

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21 December 2017