A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease. (Q45290510)

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16 February 2020

title

A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease (English)

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Huu Phuc Nguyen

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16 February 2020

author name string

Alexander P Osmand

3

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Adriana Redensek

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Larry Park

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David Howland

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Xiaofeng Gu

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Bernd Pichler

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X William Yang

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Libo Yu-Taeger

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Elisabeth Petrasch-Parwez

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Silke Metzger

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Carsten Calaminus

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Olaf Riess

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language of work or name

English

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publication date

1 October 2012

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16 February 2020

published in

Journal of Neuroscience

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volume

32

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issue

44

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page(s)

15426-15438

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describes a project that uses

16 February 2020

ImageJ

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inferred from PubMed Central ID database lookup

cites work

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

12 December 2020

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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Huntington aggregates may not predict neuronal death in Huntington's disease

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Intranuclear inclusions in subtypes of striatal neurons in Huntington's disease transgenic mice

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Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

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12 December 2020

Mouse models of Huntington's disease

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12 December 2020

Transgenic rat model of Huntington's disease

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Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study.

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The neostriatal mosaic: multiple levels of compartmental organization

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Neurobehavioral assessment in the information age.

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[Huntington's chorea]

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Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

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12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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12 December 2020

Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease.

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12 December 2020

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

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12 December 2020

Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats

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12 December 2020

Normal sensitivity to excitotoxicity in a transgenic Huntington's disease rat.

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12 December 2020

Body weight is modulated by levels of full-length huntingtin

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12 December 2020

Patterns of cell and fiber vulnerability in the mesostriatal system of the mutant mouse weaver. I. Gradients and compartments

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12 December 2020

Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease.

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12 December 2020

Imaging polyglutamine deposits in brain tissue

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12 December 2020

Cellular and subcellular localization of Huntingtin [corrected] aggregates in the brain of a rat transgenic for Huntington disease

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12 December 2020

Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males

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12 December 2020

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.

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12 December 2020

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

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12 December 2020

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

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12 December 2020

Striosome-matrix pathology and motor deficits in the YAC128 mouse model of Huntington's disease

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12 December 2020

Mouse models of Huntington disease: variations on a theme.

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12 December 2020

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

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12 December 2020

Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance.

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12 December 2020

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

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12 December 2020

Species differences in pharmacokinetics and pharmacodynamics.

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12 December 2020

Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis

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12 December 2020

Formation and toxicity of soluble polyglutamine oligomers in living cells

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12 December 2020

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

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12 December 2020

Huntington's Disease: Can Mice Lead the Way to Treatment?

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12 December 2020

Metabolic and type 1 cannabinoid receptor imaging of a transgenic rat model in the early phase of Huntington disease.

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12 December 2020

Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice

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12 December 2020

Genotype specific age related changes in a transgenic rat model of Huntington's disease

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12 December 2020

Microstructural changes observed with DKI in a transgenic Huntington rat model: evidence for abnormal neurodevelopment

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12 December 2020

Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner.

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12 December 2020

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

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12 December 2020

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders

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12 December 2020

Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats

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12 December 2020

Differential loss of striatal projection neurons in Huntington disease

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12 December 2020

Loss of matrix calcium-binding protein-containing neurons in Huntington's disease

1 reference

12 December 2020

Neuropathological classification of Huntington's disease

1 reference

12 December 2020

Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease

1 reference

12 December 2020

Neostriatal projections from individual cortical fields conform to histochemically distinct striatal compartments in the rat.

1 reference

12 December 2020

Cytoarchitectonic heterogeneity of the primate neostriatum: subdivision into Island and Matrix cellular compartments

1 reference

12 December 2020

Early loss of neostriatal striosome neurons in Huntington's disease

1 reference

12 December 2020

Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15.

1 reference

12 December 2020

Trinucleotide repeat length instability and age of onset in Huntington's disease

1 reference

12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Neurochemical architecture of the human striatum

1 reference

12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

12 December 2020

Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome

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12 December 2020

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12 December 2020

Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.

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12 December 2020

10.1523/JNEUROSCI.1148-12.2012

Identifiers

DOI

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PubMed publication ID

23115180

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